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Influenza virus vaccine, quadrivalent (IIV4), split virus, preservative free, 0.5 mL dosage, for intramuscular use

CPT4 code

Name of the Procedure:

Influenza Virus Vaccine, Quadrivalent (IIV4), Split Virus, Preservative-Free, 0.5 mL Dosage, for Intramuscular Use


This procedure involves the administration of a preservative-free quadrivalent influenza vaccine, which helps protect against four strains of the flu virus. The vaccine is given as a 0.5 mL injection into a muscle, typically in the upper arm.


  • Medical Condition Addressed: Influenza (Flu).
  • Goals: To prevent flu infection, reduce the severity of flu symptoms, and decrease the risk of flu-related complications.


  • Specific Symptoms/Conditions: Recommended for individuals aged 6 months and older, particularly those at higher risk for flu complications.
  • Patient Criteria: Individuals with chronic health conditions, healthcare workers, pregnant women, and those in close contact with high-risk populations.


  • Pre-Procedure Instructions: Usually none required; patients should inform healthcare providers of any allergies or current medications.
  • Diagnostic Tests/Assessments: Generally, no specific tests are needed before receiving the vaccine.

Procedure Description

  1. Step-by-Step Explanation:
    • The patient is seated, and the upper arm is exposed.
    • The injection site is cleaned with an antiseptic wipe.
    • A healthcare professional administers a 0.5 mL injection of the vaccine into the deltoid muscle.
    • A band-aid is applied to the injection site.
  2. Tools/Equipment: Syringe, 0.5 mL of preservative-free IIV4 vaccine.
  3. Anesthesia/Sedation: No anesthesia or sedation is required.


The injection process typically takes a few minutes, with a 15-minute observation period afterward to monitor for any immediate adverse reactions.


The procedure is performed in an outpatient setting, such as a doctor's office, clinic, or pharmacy.


  • Healthcare Professionals Involved: Nurse or physician.

Risks and Complications

  • Common Risks: Soreness at the injection site, mild fever, fatigue, muscle aches.
  • Rare Risks: Severe allergic reactions (anaphylaxis), Guillain-Barré syndrome.


  • Expected Benefits: Protection against four strains of the flu, reduction in flu-related complications, and decreased transmission of the flu virus.
  • Timeframe: Immunity typically develops within two weeks after vaccination.


  • Post-Procedure Care: Minimal; patients may take over-the-counter pain relievers for injection site soreness.
  • Recovery Time: Immediate return to normal activities; minor soreness or fatigue may last 1-2 days.
  • Follow-Up: Annual vaccination is recommended to maintain protection.


  • Other Treatment Options: Other types of flu vaccines (e.g., trivalent, live attenuated nasal spray).
  • Pros and Cons: Quadrivalent vaccines offer broader protection against more flu strains. Nasal spray vaccines are an alternative for those who fear needles but are not suitable for everyone.

Patient Experience

  • During the Procedure: Patients will feel a quick pinch or sting at the injection site.
  • After the Procedure: Mild soreness, redness, or swelling at the injection site. Symptoms like low-grade fever or fatigue may occur but are usually brief. Pain can be managed with over-the-counter medications.

Overall, the quadrivalent influenza vaccine is a safe and effective way to protect against the flu and its complications, with minimal discomfort.

Medical Policies and Guidelines for Influenza virus vaccine, quadrivalent (IIV4), split virus, preservative free, 0.5 mL dosage, for intramuscular use

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