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Influenza virus vaccine, trivalent (IIV3), split virus, preservative free, 0.25 mL dosage, for intramuscular use

CPT4 code

Name of the Procedure:

Influenza Virus Vaccine, Trivalent (IIV3), Split Virus, Preservative Free, 0.25 mL Dosage, for Intramuscular Use


This procedure involves the administration of a trivalent influenza vaccine (IIV3), which is designed to protect against three different strains of the flu virus. The vaccine is preservative-free, split virus, and administered in a 0.25 mL dosage via an intramuscular injection.


The primary purpose of this procedure is to immunize individuals against influenza, reducing the risk of contracting the flu. The expected outcome is increased immunity to the circulating strains of the influenza virus covered by the vaccine.


  • Individuals who are at higher risk for complications from influenza, such as young children, elderly adults, and those with chronic health conditions.
  • Persons who wish to protect themselves from the influenza virus.
  • Patients who are eligible and prefer a preservative-free vaccine option.


  • No specific fasting or dietary restrictions required.
  • Inform the healthcare provider of any allergies or previous adverse reactions to vaccines.
  • It is generally recommended to be in good health and not currently experiencing a fever.

Procedure Description

  1. The healthcare provider will explain the procedure and obtain consent.
  2. The injection site will be cleaned with an antiseptic wipe.
  3. The trivalent vaccine (0.25 mL) is drawn into a sterile syringe.
  4. The vaccine is then injected intramuscularly, typically into the upper arm (deltoid muscle).
  5. A small bandage may be applied to the injection site.

    Tools/Equipment: Sterile syringe, antiseptic wipe, bandage. Anesthesia: None required.


The entire procedure typically takes about 5-10 minutes.


The procedure is usually performed in an outpatient clinic, doctor's office, or hospital setting.


  • Licensed healthcare provider (e.g., nurse, doctor, or trained medical assistant) will administer the vaccine.

Risks and Complications

  • Common: Mild pain, redness, or swelling at the injection site; low-grade fever; muscle aches.
  • Rare: Severe allergic reaction (anaphylaxis), although this is extremely rare. Emergency medical treatment may be required.


  • Protection against the three strains of influenza covered by the vaccine.
  • Reduced risk of influenza-related complications.
  • Benefits typically begin within two weeks of vaccination.


  • Most individuals can resume normal activities immediately after the injection.
  • Monitor the injection site for any signs of an adverse reaction.
  • Keep the vaccinated area clean and dry.


  • Quadrivalent influenza vaccine, which covers four strains of the flu virus.
  • Nasal spray flu vaccine.
  • Annual vaccination remains the most effective way to prevent influenza.

Patient Experience

  • The injection may cause mild discomfort or a brief stinging sensation.
  • Post-injection, some individuals may experience minor side effects like soreness or low-grade fever, which generally resolve within a few days.
  • Pain management: Over-the-counter pain relievers can be used to ease any discomfort.

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