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Influenza virus vaccine, quadrivalent (IIV4), inactivated, adjuvanted, preservative free, 0.25 mL dosage, for intramuscular use

CPT4 code

Name of the Procedure:

Influenza Virus Vaccine, Quadrivalent (IIV4), Inactivated, Adjuvanted, Preservative-Free, 0.25 mL Dosage, for Intramuscular Use. Commonly known as the flu shot.


The influenza virus vaccine is administered through a shot into the muscle. It is designed to protect against four different flu viruses. This version of the vaccine is inactivated (contains no live virus), adjuvanted (enhanced for better immune response), and does not contain preservatives.


The procedure aims to prevent seasonal flu, which can cause mild to severe illness and at times lead to death. The vaccine helps the body's immune system recognize and fight the flu virus if exposed.


  • Individuals aged 6 months and older to protect against seasonal flu.
  • Particularly recommended for children, elderly, pregnant women, and those with chronic health conditions or weakened immune systems.


  • No special preparation is required for most individuals.
  • Inform your healthcare provider about any severe allergies, previous adverse reactions to flu vaccines, or current health conditions.
  • Wear a short-sleeved shirt or loose clothing for easy access to the upper arm.

Procedure Description

  1. The healthcare provider will clean the injection site (upper arm) with an antiseptic.
  2. Using a sterile syringe, they will draw 0.25 mL of the vaccine.
  3. The vaccine is injected into the muscle of the upper arm.
  4. A small bandage may be applied to the injection site.


The procedure typically takes about 5-10 minutes, including the time for vaccine preparation and administration.


The procedure is performed in outpatient clinics, hospitals, doctors' offices, pharmacies, or other healthcare facilities.


The vaccine is usually administered by trained healthcare professionals such as nurses or pharmacists.

Risks and Complications

  • Common: Soreness, redness, or swelling at the injection site; mild fever; fatigue; muscle aches.
  • Rare: Severe allergic reactions (anaphylaxis), Guillain-Barre Syndrome (GBS), or other very rare neurological conditions.


  • Reduced risk of contracting flu.
  • Lowered severity of symptoms if flu is contracted.
  • Reduction in flu-related complications and hospitalizations.
  • Immunity development within about two weeks post-vaccination.


  • Minor discomfort or soreness at the injection site may occur.
  • Normal activities can generally be resumed immediately.
  • If experiencing severe side effects, contact a healthcare provider.


  • Nasal spray flu vaccine (not suitable for everyone, such as pregnant women or those with certain medical conditions).
  • Antiviral medications, if you contract the flu.
  • Alternative preventative measures such as good hygiene practices and avoiding close contact with infected individuals.

Patient Experience

  • Patients might feel a brief, sharp pain at the injection site.
  • Some might experience mild flu-like symptoms, which are usually short-lived.
  • Over-the-counter pain relievers can be taken to manage any discomfort.

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