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Influenza virus vaccine, quadrivalent (IIV4), split virus, 0.25 mL dosage, for intramuscular use

CPT4 code

Name of the Procedure:

Influenza Virus Vaccine, Quadrivalent (IIV4), Split Virus, 0.25 mL Dosage, Intramuscular Use


The Influenza Virus Vaccine, Quadrivalent (IIV4), is an injection given to protect against four strains of the flu. This vaccine is administered into a muscle, typically in the upper arm.


The primary goal of the IIV4 vaccination is to prevent influenza infection and its complications. It aims to reduce the risk of flu-related illness, hospitalizations, and deaths.


  • Annual vaccination recommended for individuals six months and older.
  • Especially important for those at higher risk of flu complications, such as young children, elderly people, pregnant women, and individuals with certain chronic health conditions.


  • No special preparation is generally needed.
  • Inform your healthcare provider of any allergies or medical conditions.
  • You may be asked about any current medications.

Procedure Description

  1. Patient Preparation: The patient is seated comfortably.
  2. Site Selection: The healthcare professional selects an appropriate injection site, typically the upper arm.
  3. Injection: Using a sterilized syringe, 0.25 mL of the vaccine is injected into the muscle.
  4. Post-Injection: The site is covered with a small bandage if needed.


The entire process usually takes about 5-10 minutes.


This procedure is typically performed in the doctor's office, outpatient clinic, pharmacy, or other healthcare settings.


Administered by a trained healthcare professional, such as a nurse, doctor, or pharmacist.

Risks and Complications

  • Common: Soreness at the injection site, mild fever, fatigue, and headache.
  • Rare: Severe allergic reactions, such as anaphylaxis. Management includes immediate medical attention if severe reactions occur.


  • Reduced risk of contracting influenza.
  • Lower probability of flu-related complications and hospitalizations.
  • Protection starts about two weeks after vaccination.


  • Some mild side effects like soreness or mild fever may occur but typically resolve within a few days.
  • No significant downtime is required, and normal activities can usually be resumed immediately.


  • Other forms of flu vaccines, such as the live attenuated influenza vaccine (LAIV), administered as a nasal spray.
  • Antiviral medications for those who cannot be vaccinated, though these do not replace the vaccine.

Patient Experience

  • During the injection: Mild discomfort or a brief sting may be felt.
  • After the injection: Mild side effects like soreness or fatigue are possible; these can be managed with over-the-counter pain relievers and rest.

Medical Policies and Guidelines for Influenza virus vaccine, quadrivalent (IIV4), split virus, 0.25 mL dosage, for intramuscular use

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