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Influenza virus vaccine, trivalent (IIV3), split virus, 0.5 mL dosage, for intramuscular use

CPT4 code

Name of the Procedure:

Influenza Virus Vaccine, Trivalent (IIV3), Split Virus, 0.5 mL Dosage, for Intramuscular Use


The trivalent influenza virus vaccine (IIV3) is a flu shot administered intramuscularly to protect individuals against three strains of the influenza virus. This vaccine is given as a 0.5 mL injection, commonly in the upper arm.


The influenza vaccine aims to prevent the flu, a contagious respiratory illness causing mild to severe symptoms. It reduces the risk of flu-related complications, hospitalizations, and death, especially in vulnerable populations.


  • Individuals aged 6 months and older.
  • Those with chronic health conditions (e.g., asthma, diabetes).
  • Pregnant women.
  • Healthcare workers and others at high risk of flu exposure.
  • Elderly individuals (65 years and older).


  • No specific fasting required.
  • Wear clothing that allows easy access to the upper arm.
  • Inform healthcare providers of any medical conditions or allergies.
  • Review any current medications, especially blood thinners.
  • Diagnostic tests not generally required.

Procedure Description

  1. Pre-Injection: The healthcare provider will verify patient information and discuss any concerns.
  2. Positioning: The patient is usually seated or standing.
  3. Injection Site: The skin of the upper arm (deltoid muscle) is cleaned with an alcohol swab.
  4. Administration: Using a sterile needle, 0.5 mL of the IIV3 vaccine is injected into the muscle.
  5. Post-Injection: The site is observed for a few minutes to check for any immediate reactions.


The vaccination process takes approximately 5-10 minutes.


Typically administered in a healthcare provider’s office, a clinic, a pharmacy, or a community health fair.


  • Administered by trained healthcare professionals such as nurses or pharmacists.

Risks and Complications

  • Common: Soreness, redness, or swelling at the injection site, mild fever, headache, or muscle aches.
  • Rare: Severe allergic reactions (anaphylaxis), Guillain-Barré syndrome.


  • Reduced risk of contracting the flu.
  • Decreased severity of symptoms if the flu is contracted.
  • Lowered risk of flu-related complications, especially in high-risk groups.
  • Benefits generally realized within two weeks of vaccination.


  • Minimal recovery required.
  • Monitor for side effects for a few days.
  • Normal activities can usually be resumed immediately.
  • Follow up with a healthcare provider if severe reactions occur.


  • Quadrivalent Influenza Vaccine (IIV4): Protects against four strains of the flu virus.
  • Live Attenuated Influenza Vaccine (LAIV): Nasal spray alternative, not suitable for everyone.
  • Antiviral Medications: Can be prescribed if the flu is contracted but do not prevent it.

Patient Experience

  • Mild discomfort at the injection site is common.
  • Some patients may experience a mild fever or muscle aches.
  • Pain management can include over-the-counter pain relievers like acetaminophen or ibuprofen.
  • Most side effects are mild and resolve within a few days.

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