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Influenza virus vaccine (IIV), pandemic formulation, split virus, for intramuscular use

CPT4 code

Name of the Procedure:

Influenza Virus Vaccine (IIV), Pandemic Formulation, Split Virus, Intramuscular Use


This procedure involves administering a flu vaccine specifically formulated for pandemic influenza. The vaccine contains inactivated (split) virus particles and is given via an intramuscular injection to help the body develop immunity against the specific strain of influenza causing the pandemic.


The pandemic influenza vaccine aims to protect individuals from the specific strain of influenza virus causing a pandemic. The goal is to reduce the severity of illness, prevent complications, and decrease the spread of the virus within the community.


  • Presence of a declared pandemic influenza
  • Individuals with a higher risk of severe illness from influenza, such as elderly patients, those with chronic diseases, and healthcare workers
  • General population as advised by public health authorities


  • No special preparation is usually required.
  • It is advisable to inform your healthcare provider about any allergies, current medications, and medical history.
  • Some individuals might undergo a brief assessment, such as a temperature check.

Procedure Description

  1. The healthcare provider will clean the area of the upper arm (deltoid muscle) with an antiseptic wipe.
  2. Using a sterile syringe, the provider will administer the vaccine intramuscularly.
  3. The injection site may be covered with a small bandage.


The injection itself takes only a few seconds, but the entire appointment may last around 10-15 minutes, allowing time for preparation and a brief observation period afterward.


The vaccine is typically administered in a clinic, outpatient setting, pharmacy, or a public health vaccination site.


  • Registered Nurse (RN)
  • Licensed Practical Nurse (LPN)
  • Medical Assistant (MA)
  • Pharmacist

Risks and Complications

  • Common: Soreness at injection site, mild fever, fatigue, headache
  • Rare: Severe allergic reactions (anaphylaxis), Guillain-Barre Syndrome
  • Management: Use of antihistamines or epinephrine in the event of an allergic reaction; close monitoring for complications


  • Protection from the pandemic strain of influenza
  • Reduced severity of the illness if contracted
  • Decreased risk of complications such as pneumonia
  • Expected benefits may be realized within a couple of weeks post-vaccination as the immune system builds protection


  • Mild symptoms like sore arm or mild fever generally resolve within a few days.
  • No significant downtime is necessary; normal activities can usually be resumed immediately.
  • Follow-up is typically not required, but keep track of any unusual symptoms and inform a healthcare provider if they occur.


  • Antiviral medications for influenza treatment
  • Non-pandemic seasonal influenza vaccines (less likely to be effective against pandemic strains)
  • Preventive measures like hand hygiene, wearing masks, and social distancing

Patient Experience

  • The injection might cause brief discomfort or a stinging sensation.
  • Post-procedure, mild soreness and flu-like symptoms can occur but are usually short-lived.
  • Pain management: Over-the-counter pain relievers (like acetaminophen or ibuprofen) can be used to alleviate discomfort.

--- This markdown description offers a comprehensive overview of the Influenza Virus Vaccine (Pandemic Formulation), covering essential details to ensure understanding and readiness for the procedure.

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