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Influenza virus vaccine, quadrivalent (IIV4), split virus, preservative free, for intradermal use

CPT4 code

Name of the Procedure:

Influenza Virus Vaccine, Quadrivalent (IIV4), Split Virus, Preservative-Free, for Intradermal Use


The Influenza Virus Vaccine, Quadrivalent (IIV4), is an annual flu shot administered intradermally, meaning just beneath the surface of the skin. It is designed to protect against four different strains of the influenza virus.


The procedure aims to provide immunity against the influenza virus, reducing the risk of contracting the flu and its potential complications such as severe respiratory illness, hospitalization, and death.


  • Individuals aged 18-64 who require protection against the influenza virus.
  • People with weakened immune systems or those with chronic health conditions that put them at increased risk for flu complications.


  • No specific preparation such as fasting is required.
  • Inform the healthcare provider about any severe allergies or previous adverse reactions to flu vaccines.

Procedure Description

  1. The patient will be seated and the intradermal injection site (usually the upper arm) will be cleaned with an antiseptic.
  2. A small needle will be used to inject the vaccine into the skin's surface layer.
  3. The procedure typically involves minimal discomfort and is completed within minutes.


The actual injection takes a few seconds, with the entire process lasting approximately 5-10 minutes including preparation.


This procedure is often performed in outpatient settings such as doctor's offices, clinics, or pharmacies.


  • A trained healthcare provider, such as a nurse or medical assistant, will administer the vaccine.

Risks and Complications

  • Common: Mild pain, redness, or swelling at the injection site.
  • Rare: Severe allergic reactions, such as anaphylaxis.
  • Manageable with immediate medical care.


  • Reduced risk of contracting influenza.
  • Protection against multiple strains of flu, offering broader coverage.
  • Benefits typically begin within two weeks of vaccination.


  • Minimal recovery time; patients can resume normal activities immediately.
  • Monitor for any adverse reactions for 24-48 hours post-vaccination.
  • Follow-up only if severe side effects occur.


  • Other forms of the influenza vaccine (e.g., intramuscular injections).
  • Options for individuals who cannot receive vaccines due to severe allergies or other contraindications.

Patient Experience

  • Mild discomfort during the injection.
  • Minor localized pain or itching at the injection site.
  • Rarely, mild flu-like symptoms that resolve within a few days.

Overall, the quadrivalent intradermal flu vaccine is a safe and effective way to reduce the risk of influenza and its associated health complications.

Medical Policies and Guidelines for Influenza virus vaccine, quadrivalent (IIV4), split virus, preservative free, for intradermal use

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