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Influenza virus vaccine, trivalent (IIV3), split virus, preservative-free, for intradermal use

CPT4 code

Name of the Procedure:

Influenza Virus Vaccine, Trivalent (IIV3), Split Virus, Preservative-Free, Intradermal Use

  • Common Names: Flu Shot, Influenza Vaccine


The influenza virus vaccine is an annual immunization given to protect against the flu. This particular form of the vaccine is trivalent, meaning it guards against three strains of the flu virus. It is preservative-free and administered intradermally, just below the surface of the skin.


The influenza vaccine aims to prevent infections caused by the influenza virus. The primary goal is to reduce the incidence of flu-related illnesses, hospitalizations, and complications, especially in vulnerable populations.


  • Children and adults who require seasonal flu protection, especially those who are at higher risk (e.g., elderly, young children, pregnant women, individuals with chronic health conditions)
  • Healthcare workers and caregivers who are at increased risk of spreading the flu
  • Persons with a history of severe allergic reaction to the flu vaccine should consult their healthcare provider


  • Patients may need to provide a history of allergies and medical conditions.
  • No specific preparation such as fasting is required.
  • Inform the vaccinator if you are feeling unwell or have a fever.

Procedure Description

  1. Clean the skin with an antiseptic at the injection site, usually the upper arm.
  2. Use a pre-filled syringe to deliver the vaccine intradermally (just under the skin) rather than into the muscle.
  3. The injection is typically quick and completed within seconds.
  4. Apply a small bandage if needed.
  • Tools: Syringe, Vaccine vial
  • Anesthesia/Sedation: None typically required


The vaccine administration takes only a few minutes.


Typically administered in outpatient settings such as:

  • Doctor’s offices
  • Healthcare clinics
  • Pharmacies
  • Community health centers


  • Administered by trained healthcare professionals such as nurses, pharmacists, or doctors.

Risks and Complications

  • Common: Redness, swelling, or soreness at the injection site; mild fever; muscle aches
  • Rare: Severe allergic reaction (anaphylaxis), Guillain-Barre Syndrome (extremely rare)


  • Reduced risk of contracting the flu.
  • Decreased likelihood of severe flu-related complications.
  • Typically, immune protection develops within two weeks of vaccination.


  • Minimal post-procedure care; patients can resume normal activities immediately.
  • Mild pain or swelling at the injection site can be managed with over-the-counter pain relievers like acetaminophen or ibuprofen.
  • No significant recovery time is required.


  • Quadrivalent Influenza Vaccine: Protects against four strains of the flu virus.
  • Nasal Spray Flu Vaccine: A live attenuated vaccine alternative for certain populations.

Patient Experience

  • The patient may feel a quick pinch or slight pressure during the injection.
  • Post-injection, the area may be tender or slightly swollen.
  • Most side effects, if any, are mild and resolve within a day or two.
  • Patients are usually observed briefly for any immediate adverse reactions before leaving the vaccination site. Pain management and comfort measures are generally straightforward, with the majority of patients experiencing minimal discomfort.

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