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Influenza virus vaccine (IIV), split virus, preservative free, enhanced immunogenicity via increased antigen content, for intramuscular use

CPT4 code

Name of the Procedure:

Influenza Virus Vaccine (IIV), Split Virus, Preservative-Free, Enhanced Immunogenicity via Increased Antigen Content, for Intramuscular Use.

Common name: Flu Vaccine with Increased Antigen Content


The flu vaccine with increased antigen content is an intramuscular injection designed to boost the immune response, providing better protection against the influenza virus. It is preservative-free and contains a higher amount of antigens to enhance its effectiveness.


This vaccine aims to protect individuals from the influenza virus by inducing a strong immune response. It is particularly beneficial for those at higher risk of severe flu complications. The expected outcome is a reduced likelihood of contracting the flu and decreased severity if infection occurs.


  • Individuals aged 65 and older
  • Adults with chronic health conditions such as diabetes, heart disease, or respiratory issues
  • Individuals with weak immune systems
  • Pregnant women
  • Healthcare workers and caregivers


  • Inform your healthcare provider of any allergies, especially to eggs or previous vaccine reactions.
  • No specific preparations such as fasting are required.
  • You may be asked about your current health and any underlying conditions.

Procedure Description

  1. A healthcare provider will clean the injection site, usually the upper arm.
  2. The vaccine is then administered intramuscularly using a sterile needle.
  3. Pressure or a small bandage may be applied to the site afterward.
  4. Observation for a short period to monitor for any immediate adverse reactions.

Tools: Sterile needle and syringe, flu vaccine.


The injection itself takes only a few minutes, with an additional 15-minute observation period for safety.


Administered at doctor's offices, outpatient clinics, pharmacies, or hospitals.


The vaccine is typically administered by a nurse, doctor, or trained healthcare professional.

Risks and Complications

  • Common: Soreness at the injection site, mild fever, and muscle aches.
  • Rare: Severe allergic reactions (anaphylaxis), Guillain-Barre Syndrome.

Management of Complications: Immediate medical attention for severe reactions, supportive care for mild side effects.


  • Enhanced protection against the influenza virus.
  • Reduced risk of severe flu complications.
  • Expected benefits typically realized within two weeks post-vaccination.


  • No significant downtime.
  • Monitor for any side effects for 24-48 hours.
  • Follow-up with healthcare provider in case of any unusual symptoms.


  • Standard flu vaccine (lower antigen content)
  • Nasal spray flu vaccine (live attenuated)
  • Antiviral medications for flu treatment

Pros and Cons of Alternatives:

  • Standard vaccine: Suitable for broader population but with standard immunogenicity.
  • Nasal spray: Non-invasive but not suitable for certain populations.
  • Antivirals: Treat flu but do not prevent it.

Patient Experience

  • Minor pain or discomfort at the injection site.
  • Possible mild flu-like symptoms.
  • Mostly return to normal activities immediately after, with monitoring for side effects.
  • Pain management includes over-the-counter pain relievers if necessary.

Medical Policies and Guidelines for Influenza virus vaccine (IIV), split virus, preservative free, enhanced immunogenicity via increased antigen content, for intramuscular use

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