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Influenza virus vaccine, quadrivalent (ccIIV4), derived from cell cultures, subunit, preservative and antibiotic free, 0.5 mL dosage, for intramuscular use

CPT4 code

Name of the Procedure:

Influenza Virus Vaccine, Quadrivalent (ccIIV4), Cell Culture-Derived, Subunit, Preservative and Antibiotic Free, 0.5 mL Dosage for Intramuscular Use


The quadrivalent influenza vaccine (ccIIV4) is a flu shot made from virus proteins grown in cell cultures. It is given as an injection into the muscle to protect against four different influenza virus strains. This version is free from preservatives and antibiotics.


The flu vaccine aims to prevent influenza, commonly known as the flu. The goal is to reduce the risk of getting the flu, decrease the severity if you do get sick, and prevent the spread of the virus to others.


  • People aged 6 months and older
  • Individuals with chronic health conditions (e.g., asthma, diabetes, heart disease)
  • Pregnant women
  • Healthcare workers and caregivers
  • Elderly individuals
  • People with weakened immune systems


  • No special preparation, such as fasting, is required.
  • Inform your healthcare provider of any allergies, especially to eggs or prior vaccines.
  • Provide a full medical history, including current medications.

Procedure Description

  1. Preparation: The healthcare provider will clean the injection site, usually the upper arm.
  2. Injection: A 0.5 mL dose of the vaccine is drawn into a syringe.
  3. Administration: The vaccine is injected into the muscle, typically in the deltoid.
  4. Post-Injection Care: A brief wait period (around 15 minutes) to monitor for any immediate reactions.

No anesthesia or sedation is needed.


The actual injection takes a few minutes, with a total visit time of about 15-30 minutes including monitoring.


Administered in hospitals, outpatient clinics, pharmacies, or doctor's offices.


  • Nurses
  • Doctors
  • Pharmacists

Risks and Complications

  • Common: Mild soreness at the injection site, mild fever, muscle aches.
  • Rare: Allergic reactions, including anaphylaxis.
  • Management includes antihistamines or emergency medical care if severe reactions occur.


  • Reduces the risk of getting the flu and its complications.
  • Protection begins about two weeks after vaccination and lasts for the flu season.
  • Decreases the severity of illness if you do catch the flu.


  • Minimal recovery; normal activities can usually be resumed immediately.
  • Keep the injection site clean.
  • Over-the-counter pain relievers can be taken if there is soreness.


  • Live attenuated influenza vaccine (nasal spray), suitable for certain age groups.
  • Traditional egg-based influenza vaccines.
    • Pros: Different formulations may be suitable for those with specific allergies.
    • Cons: Nasal spray may not be suitable for immunocompromised individuals.

Patient Experience

  • The injection is generally quick and might cause mild discomfort.
  • Post-injection soreness or mild flu-like symptoms are common.
  • Pain can be managed with over-the-counter medications and cold compresses as needed.

Medical Policies and Guidelines for Influenza virus vaccine, quadrivalent (ccIIV4), derived from cell cultures, subunit, preservative and antibiotic free, 0.5 mL dosage, for intramuscular use

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