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Influenza virus vaccine, trivalent, live (LAIV3), for intranasal use

CPT4 code

Name of the Procedure:

Influenza Virus Vaccine, Trivalent, Live (LAIV3), Intranasal Use


The Influenza Virus Vaccine, Trivalent, Live (LAIV3) is a nasal spray vaccine designed to protect against three strains of the influenza virus. This live, attenuated vaccine is administered intranasally (through the nose).


  • Medical Condition or Problem: Prevention of influenza (flu).
  • Goals or Expected Outcomes: To induce immunity and reduce the incidence of flu-related complications such as hospitalizations and severe illness.


  • Symptoms or Conditions: Useful for those seeking to prevent seasonal flu, especially before flu season.
  • Patient Criteria: Recommended for healthy individuals aged 2 through 49 who are not pregnant.


  • Pre-procedure Instructions: There are generally no special preparations such as fasting.
  • Diagnostic Tests or Assessments: Inform the healthcare provider of any allergies, medical conditions, or current medications.

Procedure Description

  1. The patient is seated comfortably.
  2. The healthcare provider prepares the nasal spray vaccine.
  3. The vaccine is administered as a fine mist into each nostril.
    • Tools, Equipment, or Technology: Pre-filled nasal spray device.
    • Anesthesia or Sedation: Not required.


The administration procedure typically takes just a few minutes.


This vaccine is usually administered in an outpatient clinic, doctor's office, or pharmacy.


  • Healthcare Professionals Involved: Typically administered by a nurse, physician, or other trained healthcare provider.

Risks and Complications

  • Common Risks: Mild symptoms such as runny nose, nasal congestion, sore throat, or fever.
  • Rare Risks: Severe allergic reactions, such as anaphylaxis, though very rare.
  • Possible Complications: Guillain-Barre syndrome, though this is exceedingly rare.


  • Expected Benefits: Effective in preventing the flu and reducing the severity of flu symptoms if one does contract the virus. Immunity typically develops within two weeks of vaccination.


  • Post-procedure Care and Instructions: Generally, no specific care is required after the vaccination.
  • Expected Recovery Time: Immediate return to normal activities.
  • Restrictions or Follow-up Appointments: Follow-up only if experiencing severe reactions.


  • Other Treatment Options: Inactivated influenza vaccines (injectable).
  • Pros and Cons of Alternatives: Injectable vaccines may be a better option for those who are pregnant, have certain medical conditions, or are within a different age range.

Patient Experience

  • During the Procedure: The patient may feel a slight tickle or discomfort in the nose.
  • After the Procedure: Mild symptoms like a runny nose may occur; pain management is generally not necessary. Patients can resume their regular activities immediately.

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