Name of the Procedure:

Injection, hyaluronidase, ovine, preservative-free, per 1000 USP units (J3472)

Common Names:

• Hyaluronidase Injection
• Ovine Hyaluronidase

Technical/Medical Term:

• J3472 Injection, hyaluronidase, ovine, preservative free, per 1000 USP units

Summary

Hyaluronidase is an enzyme that helps to improve the absorption and dispersion of other injected drugs or fluids. It is derived from sheep (ovine) and is preservative-free, ensuring a lower risk of allergic reactions for the patient.

Purpose

Hyaluronidase is used to enhance the dispersion and absorption of other medications. It can help treat conditions where quick drug dissemination is beneficial or correct issues like edema where fluid needs to be distributed more effectively.

Goals:

• Improved absorption of injected medications or fluids.
• Better management of localized edema or bruising.

Indications

• To facilitate the dispersion and absorption of other injected drugs or fluids.
• Treatment of extravasation of hyperosmolar or other irritating solutions.
• Management of localized edema post-surgery or injury.

Patient Criteria:

• Patients receiving subcutaneous or intramuscular injections.
• Patients with localized fluid retention needing quicker drug dissemination.

Preparation

Pre-procedure Instructions:

• No specific fasting required.
• Patients should inform their healthcare provider about any allergies or current medications.

Diagnostic Tests:

• No specific diagnostic tests required beforehand.

Procedure Description

1. Preparation: The injection site is cleaned and disinfected.
2. Injection: Hyaluronidase is injected subcutaneously or intramuscularly in the area requiring treatment.
3. Follow-Up: The target drug or fluid is injected into the same site.

Tools & Equipment:

• Sterile syringes and needles.
• Hyaluronidase solution (preservative-free).

Anesthesia/Sedation:

• Generally, none required. Local numbing may be provided if necessary.

Duration

The procedure typically takes about 10-15 minutes.

Setting

This procedure is usually performed in an outpatient clinic or hospital setting.

Personnel

• Trained nurse or physician administers the injection.
• Support staff may assist with preparation and monitoring.

Risks and Complications

Common Risks:

• Minor pain at the injection site.
• Redness or mild swelling.

Rare Risks:

• Allergic reactions.
• Infection at the injection site.
• Unintended spread of medication.

Complications Management:

• Monitoring for allergic reactions and providing appropriate treatment.
• Infection control practices to prevent site infections.

Benefits

Expected Benefits:

• Enhanced absorption of medications, leading to quicker therapeutic effects.
• Reduction in localized fluid retention and associated discomfort.

Benefit Realization:

• Effects are typically noticeable within minutes to hours after the injection.

Recovery

Post-Procedure Care:

• Monitor the injection site for signs of infection or adverse reactions.
• Patients can usually resume normal activities immediately after.

Recovery Time:

• Immediate with no specific restrictions.
• Follow-up appointments as necessary based on the primary condition being treated.

Alternatives

Other Treatment Options:

• Manual massage to disperse injected medications.
• Use of oral medications where absorption enhancements are not critical.

Pros and Cons:

• Alternatives might be less effective in rapidly dispersing medications.
• Hyaluronidase provides quicker and more efficient absorption but requires an injection.

Patient Experience

During the Procedure:

• Patients may feel a brief sting or discomfort at the injection site.
• Local numbness can be provided to enhance comfort.

After the Procedure:

• Minimal pain or swelling at injection site.
• Quick recovery with immediate return to normal activities.

Pain Management:

• Over-the-counter pain relief if needed.
• Cold compress to manage site swelling or discomfort.

This document provides a comprehensive overview and understanding of the medical procedure involving the injection of preservative-free ovine hyaluronidase (HCPCS code: J3472). The information is structured to guide through every aspect from preparation to recovery, ensuring clarity and support for both patients and healthcare providers.