Name of the Procedure:

Injection, hyaluronidase, recombinant, 1 USP unit
Common names: Hyaluronidase Injection

Summary

Hyaluronidase is an enzyme that helps to increase the absorption of other medications or fluids injected under the skin. This procedure involves injecting a synthetic version of hyaluronidase to break down hyaluronic acid, allowing for better distribution of fluids or drugs in the body.

Purpose

Hyaluronidase injection is used to:

• Enhance the absorption and dispersion of other injected drugs.
• Reduce tissue damage in the case of extravasation (when injected fluids leak into surrounding tissues).
• Treat pain and swelling from extravasation of certain drugs.
• Assist with subcutaneous fluid administration in dehydrated patients.

Indications

This procedure may be indicated for:

• Enhancing the effect of local anesthetics.
• Increasing the efficacy of other injectable drugs.
• Managing severe dehydration requiring subcutaneous fluid administration.
• Treating tissue damage or improving healing in specific conditions.

Preparation

• No special preparation is required for this procedure.
• Inform your healthcare provider of any allergies, current medications, or underlying health conditions.
• The healthcare provider may perform a skin sensitivity test to check for allergic reactions to hyaluronidase.

Procedure Description

1. The skin is cleaned with an antiseptic solution.
2. If necessary, a local anesthetic may be applied to minimize discomfort.
3. The hyaluronidase solution is prepared and loaded into a syringe.
4. The healthcare provider injects the hyaluronidase solution directly into the tissue under the skin.
5. Following the injection, the area may be gently massaged to facilitate the dispersion of the enzyme.

Duration

The procedure typically takes about 10-15 minutes.

Setting

This procedure is generally performed in an outpatient clinic, hospital, or surgical center.

Personnel

• Registered Nurse (RN)
• Licensed Practical Nurse (LPN)
• Physician or Physician Assistant (PA)

Risks and Complications

Common risks:

• Pain at the injection site
• Redness or swelling
• Itching or rash

Rare complications:

• Allergic reactions
• Infection at the injection site
• Bleeding or bruising

Benefits

• Improved absorption and effectiveness of other medications.
• Reduced risk of tissue damage from extravasated fluids.
• Enhanced hydration and quicker recovery for dehydrated patients.
• Immediate to short-term realization of benefits after injection.

Recovery

• You can resume normal activities immediately.
• Keep the injection site clean and dry.
• Monitor for signs of infection or adverse reactions.
• Follow-up appointments may be scheduled to assess the effectiveness of the treatment.

Alternatives

• Oral or intravenous administration of medications (with potential slower absorption).
• Use of different local anesthetic techniques.
• Direct management of the underlying condition or symptomatic treatment.

Patient Experience

• Mild discomfort or a slight stinging sensation at the injection site.
• Rapid relief of symptoms if used to treat extravasation.
• Most patients experience minimal to no pain after the procedure.

Pain management will include the option of a local anesthetic if necessary, and the healthcare provider will ensure maximum comfort throughout the procedure.