Name of the Procedure:

Injection of Hyaluronidase, Ovine, Preservative Free
Technical Term: Injection, hyaluronidase, ovine, preservative free, per 1 USP unit (up to 999 USP units) (HCPCS code: J3471)

Summary

Hyaluronidase is an enzyme derived from sheep that is used to break down hyaluronic acid in the body. This procedure involves injecting a preservative-free form of hyaluronidase to aid in the absorption of other medications or fluids.

Purpose

Hyaluronidase injections are used to treat:

• Edema (swelling) associated with surgeries or injuries.
• To enhance the absorption and dispersion of other injected drugs.
• To help administer subcutaneous (under the skin) infusions.

Indications

• Difficulty in absorbing medication or fluids due to dense tissue.
• Pain or swelling at the injection site.
• Need to rapidly administer fluids or medication subcutaneously.

Preparation

• No fasting required.
• Patients should inform healthcare providers of any allergies or ongoing medications.
• Basic health assessment to rule out contraindications.

Procedure Description

1. Preparation: The injection site is cleaned and sterilized.
2. Injection: A small needle is used to inject hyaluronidase under the skin or into the targeted tissue.
3. Completion: The area may be lightly massaged to help disperse the enzyme.

Tools/Equipment Used:

• Sterile syringes.
• Hyaluronidase solution.
• Antiseptic wipes.

Anesthesia/Sedation:

• Typically, no anesthesia is required; localized numbing may be applied if needed.

Duration

The procedure usually takes about 15-30 minutes.

Setting

This injection is typically performed in:

• Outpatient clinics.
• Doctor’s offices.
• Hospitals or surgical centers.

Personnel

• A nurse or a trained healthcare provider administers the injection.

Risks and Complications

Common Risks:

• Pain or discomfort at the injection site.
• Mild swelling or redness.

Rare Risks:

• Allergic reactions.
• Excessive swelling.
• Localized infection.

Benefits

• Enhanced absorption of medications.
• Reduced swelling and discomfort.
• Rapid administration of needed fluids or drugs.

Expected Realization:

• Immediate effects in drug absorption and fluid dispersion.

Recovery

• Minimal recovery time; patients can usually return to normal activities immediately.
• Follow-up may include monitoring for allergic reactions or signs of infection.

Alternatives

• Manual Massage: To disperse fluid buildup.
• Different Enzyme Preparations: Alternatives to hyaluronidase.
• Surgical Drainage: In cases of severe fluid accumulation.

Pros and Cons:

• Manual massage is non-invasive but less effective.
• Alternative enzymes may work differently or have different side effects.
• Surgical drainage is more invasive and involves longer recovery.

Patient Experience

• A slight pinch or stinging sensation during the injection.
• Possible mild discomfort or soreness at the site post-procedure.
• Pain management includes over-the-counter pain relievers and cold compresses if needed.