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Immune globulin (Ig), human, for intramuscular use

CPT4 code

Name of the Procedure:

Immune Globulin (Ig), Human, for Intramuscular Use
Common name(s): Intramuscular Immunoglobulin, IMIG
Technical terms: Human Immunoglobulin G (IgG), IMIG


Immune globulin for intramuscular use involves injecting human antibodies into a muscle. This treatment helps to boost the immune system, providing immediate protection against infections or helping to manage certain health conditions.


Immune globulin is used to address immune deficiencies and autoimmune disorders. The primary goals are to enhance the immune response, prevent infections, and manage symptoms of immune-related diseases.


  • Primary immunodeficiency diseases (PIDD)
  • Chronic inflammatory demyelinating polyneuropathy (CIDP)
  • Immune thrombocytopenic purpura (ITP)
  • Patients with weakened immune systems who require temporary antibody protection
  • Post-exposure prophylaxis for diseases such as hepatitis A and measles


  • No specific fasting required unless otherwise instructed by the healthcare provider.
  • Inform the healthcare provider of any allergies or medications currently being taken.
  • Possibly perform diagnostic tests to confirm the need for immune globulin therapy.

Procedure Description

  1. The patient is seated or lying down in a comfortable position.
  2. The healthcare provider cleans the injection site, typically in the upper arm or thigh.
  3. Using a sterile needle and syringe, the provider injects the immune globulin into the muscle.
  4. The injection site is then covered with a bandage.

Tools and equipment: Sterile needle and syringe, antiseptic solution, bandage.
Anesthesia/Sedation: Typically not required, as the procedure is generally quick and well-tolerated.


The procedure usually takes about 5-10 minutes.


Performed in a hospital, outpatient clinic, or healthcare provider's office.


Administered by a trained healthcare professional, such as a nurse or physician.

Risks and Complications

  • Common: Pain, redness, or swelling at the injection site.
  • Rare: Allergic reactions, including rash, itching, difficulty breathing.

Complications are generally managed promptly by healthcare professionals on site.


  • Boosts immune function to prevent infections
  • Manages symptoms of immune-related disorders
  • Provides rapid immune support

Benefits are typically realized within days to weeks following the injection.


  • Patients can typically resume normal activities immediately.
  • Follow any specific instructions provided by the healthcare professional.
  • Monitor the injection site for signs of infection or unusual reactions.
  • Schedule any follow-up appointments as necessary.


  • Intravenous immunoglobulin (IVIG) for more systemic treatment.
  • Medications or treatments specific to the underlying condition.
  • Pros: Alternatives like IVIG may be more effective for certain conditions.
  • Cons: Alternatives might require more extensive medical supervision and can be more costly.

Patient Experience

  • During the procedure, patients might feel a slight sting or discomfort at the injection site.
  • Post-procedure, mild soreness or redness may occur but usually resolves quickly.
  • Pain management typically involves over-the-counter pain relievers if needed and basic comfort measures.

Overall, the intramuscular injection of immune globulin is a widely-used procedure that provides important benefits with minimal downtime and discomfort for the patient.

Medical Policies and Guidelines for Immune globulin (Ig), human, for intramuscular use

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