D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function

ICD10CM code

#### Name of the Condition
- Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function (CVID)

#### Summary
Common variable immunodeficiency (CVID) with predominant abnormalities of B-cell numbers and function is a primary immunodeficiency disorder characterized by a significantly low level of immunoglobulins (antibodies) in the blood, resulting in increased susceptibility to infections.

#### Causes
- The exact cause of CVID is often unknown, but it is suspected to have a genetic component. Mutations in genes involved in B-cell development and function may contribute to this condition.

#### Risk Factors
- Family history of immunodeficiency disorders
- Genetic mutations affecting the immune system
- Potential connection to autoimmune conditions

#### Symptoms
- Frequent and recurrent infections, particularly of the sinuses, ears, and respiratory tract
- Chronic cough or sinusitis
- Gastrointestinal issues such as diarrhea
- Fatigue and weakness
- Enlarged spleen or lymph nodes

#### Diagnosis
- Comprehensive blood tests to assess immunoglobulin (IgG, IgA, IgM) levels
- Assessment of B-cell numbers and function
- Exclusion of other causes of immunodeficiency
- Genetic testing may be done to identify mutations

#### Treatment Options
- Immunoglobulin replacement therapy to provide the necessary antibodies
- Antibiotics to treat and prevent infections
- Regular monitoring and supportive care to manage symptoms
- In some cases, bone marrow transplant may be considered

#### Prognosis and Follow-Up
- CVID is a chronic condition, and with appropriate management, individuals can lead relatively normal lives.
- Regular follow-up with an immunologist is crucial for monitoring and adjusting treatment as necessary.

#### Complications
- Increased risk of autoimmune disorders
- Potential development of malignancies
- Risk of organ damage due to repeated infections

#### Lifestyle & Prevention
- Avoid exposure to known sources of infection
- Maintain a healthy lifestyle with a balanced diet and regular exercise
- Timely vaccinations (except live vaccines)

#### When to Seek Professional Help
- Unusual frequency or severity of infections
- Persistent symptoms like fatigue or diarrhea
- Sudden swelling of lymph nodes or spleen

#### Additional Resources
- [Immune Deficiency Foundation](https://primaryimmune.org/)
- [CVID Foundation](http://www.biotest-global.com/)

#### Tips for Medical Coders
- Ensure that the full diagnosis is included when coding to differentiate from other immunodeficiencies.
- Verify the specific predominance of B-cell abnormalities in the medical documentation.
- Avoid coding errors by confirming ICD code D83.0 for this specific subtype of CVID.

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