Name of the Procedure:

Injection, blinatumomab, 1 microgram (J9039)

• Common Name: Blinatumomab Injection
• Medical Term: Adcetris Injection

Summary

Blinatumomab injection involves administering a monoclonal antibody designed to treat certain types of cancer. The medication is directly injected into the patient's bloodstream to target and destroy cancer cells.

Purpose

Blinatumomab injection is primarily used to treat:

• Certain types of blood cancers, such as B-cell precursor acute lymphoblastic leukemia.
• The goal is to reduce or eliminate cancer cells, potentially leading to remission and preventing recurrence.

Indications

• Patients diagnosed with relapsed or refractory B-cell precursor acute lymphoblastic leukemia.
• Those who have not responded to other treatments or have experienced a recurrence of cancer.

Preparation

• Pre-procedure instructions typically include:
  • Discussing current medications with the healthcare provider.
  • Possible cessation of certain medications that might interfere with the treatment.
  • Routine blood tests and diagnostic assessments to determine current health status.

Procedure Description

1. The patient is positioned comfortably, often in a reclining chair or bed.
2. An IV line is established if not already in place.
3. Blinatumomab is prepared under sterile conditions.
4. The medication is infused intravenously over a specific period, as per protocol.
5. The infusion process is closely monitored for any adverse reactions.

Duration

• The duration of the infusion varies but typically lasts a few hours per session.
• Multiple sessions may be required over several weeks.

Setting

• The procedure is performed in a hospital or an outpatient clinic with facilities for handling chemotherapy drugs.

Personnel

• The procedure involves:
  • Oncologists or hematologists.
  • Nurses specialized in chemotherapy administration.
  • Pharmacists for medication preparation.

Risks and Complications

• Common risks include:
  • Fever, chills, and infusion reactions.
  • Nausea and vomiting.
  • Possible low blood cell counts.
• Rare risks:
  • Severe allergic reactions.
  • Neurological side effects like confusion or seizures.
  • Infections due to immune suppression.

Benefits

• The expected benefits include the reduction or elimination of cancer cells.
• Some patients may experience remission and an improved quality of life.

Recovery

• Post-procedure care involves regular monitoring of blood counts and overall health.
• Patients might experience tiredness; rest and hydration are encouraged.
• Follow-up appointments are necessary to track progress and manage any side effects.

Alternatives

• Alternative treatments include chemotherapy, radiation therapy, or other monoclonal antibodies.
• Pros and cons should be discussed with the healthcare provider to tailor the best treatment strategy.

Patient Experience

• During the procedure:
  • Mild discomfort from the IV insertion.
  • Possible side effects like chills or fever.
• After the procedure:
  • Patients may feel fatigued and should rest.
  • Management of side effects with prescribed medications and supportive care to ensure comfort and recovery.