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Chemotherapy administration, subcutaneous or intramuscular; hormonal anti-neoplastic

CPT4 code

Name of the Procedure:

Chemotherapy administration, subcutaneous or intramuscular; hormonal anti-neoplastic (commonly referred to as hormonal chemotherapy injections).


Hormonal chemotherapy injections involve administering hormonal treatments subcutaneously (under the skin) or intramuscularly (into the muscle) to treat cancer. These injections help inhibit the growth and spread of hormone-sensitive tumors.


Hormonal chemotherapy is used to treat cancers that depend on hormones to grow, such as certain types of breast and prostate cancers. The goal is to reduce the size of the tumor, prevent its spread, and alleviate symptoms associated with the cancer.


  • Hormone-sensitive breast cancer
  • Prostate cancer
  • Other cancers responsive to hormonal therapy Patients who have been diagnosed with hormone-dependent tumors and have not responded to other treatments may be suitable candidates.


  • No specific fasting required.
  • Patients may need to adjust certain medications as directed by their healthcare provider.
  • Routine blood tests may be performed to assess overall health and organ function.

Procedure Description

  1. The patient is positioned comfortably, often seated or lying down.
  2. The injection site is cleaned with an antiseptic solution.
  3. A fine needle is used to administer the medication either subcutaneously (often in the abdomen or thigh) or intramuscularly (often in the buttock or upper arm).
  4. The injection is given slowly to minimize discomfort.
  5. The site is monitored briefly for any immediate reactions.


The injection itself typically takes only a few minutes, although the entire appointment may last about 15-30 minutes.


Hormonal chemotherapy injections are usually performed in an outpatient clinic or a specialized cancer treatment center.


  • Oncologist or a specialized nurse
  • Medical assistant

Risks and Complications

  • Common risks: mild pain or discomfort at the injection site, bruising, and swelling.
  • Rare risks: allergic reaction, infection at the injection site, and hormonal imbalances. Complications are managed based on their severity, often involving symptomatic treatment and close monitoring.


  • Reduction in tumor size and spread
  • Alleviation of symptoms related to cancer
  • Improvement in overall quality of life Benefits can often be seen within weeks to months, depending on individual response.


  • Patients can usually resume normal activities immediately.
  • Instructions may include monitoring the injection site for any signs of infection or unusual reactions.
  • Follow-up appointments are scheduled to assess treatment progress and manage any side effects.


  • Oral hormonal therapies
  • Other chemotherapy regimens
  • Radiation therapy
  • Surgery Each alternative has its pros and cons, including differences in side effects, efficacy, and patient convenience.

Patient Experience

  • Patients may feel a brief sting or discomfort during the injection.
  • Mild soreness at the injection site may persist for a day or two.
  • Pain management strategies include over-the-counter pain relievers and applying a cold pack to the injection site if needed. Comfort measures include ensuring a relaxed environment and the support of qualified medical staff to address concerns and provide reassurance.

Medical Policies and Guidelines for Chemotherapy administration, subcutaneous or intramuscular; hormonal anti-neoplastic

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