Name of the Procedure:

Injection, Busulfan, 1 mg (HCPCS Code: J0594)

Summary

This procedure involves the administration of Busulfan, a chemotherapy drug, through an injection.

Purpose

Busulfan is primarily used for:

• Treatment of certain types of cancer, including chronic myeloid leukemia (CML).
• Pre-conditioning before a bone marrow or stem cell transplant.

The goal is to destroy existing cancer cells and prepare the body for a successful transplant.

Indications

• Patients diagnosed with chronic myeloid leukemia (CML).
• Individuals preparing for a bone marrow or stem cell transplant.
• Patients with certain other blood-related cancers as determined by their healthcare provider.

Preparation

• Fasting is typically not required, but follow your doctor's instructions.
• Adjustments to other medications may be necessary; consult your physician.
• Pre-procedure blood tests to assess overall health and organ function.

Procedure Description

1. The patient is positioned comfortably, usually sitting or lying down.
2. A healthcare professional administers Busulfan via an intravenous (IV) line or as an injection under the skin.
3. Monitoring for immediate reactions to the medication.
4. Sedation or anesthesia is generally not required.

Duration

• The injection process is relatively quick, typically completed within 5-10 minutes.
• Observation thereafter can take around 30 minutes to ensure no adverse reactions occur.

Setting

• The procedure is usually performed in a hospital oncology unit or an outpatient clinic.

Personnel

• An oncologist or a specialized nurse usually administers the injection.

Risks and Complications

• Common risks include nausea, vomiting, and fatigue.
• Rare risks are severe allergic reactions and organ toxicity (lungs, liver).
• Management of complications involves symptom-specific treatments, like anti-nausea medication or steroids.

Benefits

• Effective in killing cancer cells and preparing for bone marrow or stem cell transplant.
• Patients might notice improvement in symptoms within a few weeks to months.

Recovery

• Post-procedure, patients might be observed for a short time to monitor for side effects.
• Patients are advised to stay hydrated and avoid strenuous activities.
• Regular follow-up appointments to monitor progress and manage any side effects.

Alternatives

• Other chemotherapy drugs or radiation therapy.
• Targeted therapy or immunotherapy, depending on the specific cancer type and patient condition.
• Alternative treatments may vary in effectiveness and side effect profiles.

Patient Experience

• Patients might feel mild discomfort at the injection site and possible side effects like nausea or fatigue.
• Pain management includes prescribed analgesics and anti-emetics for nausea control.
• Comfort measures like rest, hydration, and supportive care are crucial during recovery.