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Clotting inhibitors or anticoagulants; protein S, total

CPT4 code

Name of the Procedure:

Clotting Inhibitors or Anticoagulants; Protein S, Total


A Protein S, total test measures the level of Protein S in your blood, which is important for controlling blood clotting. This test helps to find out if there are issues that could lead to abnormal blood clots.


This test is used to diagnose or rule out conditions that involve abnormal clotting. Elevated or decreased levels of Protein S can indicate a problem with blood clotting mechanisms, potentially preventing harmful blood clots.


Patients with a history of unexplained blood clots, thrombosis, or a family history of blood clotting disorders may need this test. It's also indicated for patients who have experienced recurrent pregnancy loss or have other symptoms of a potential clotting disorder.


Before the test, your doctor may advise you to avoid taking anticoagulant medications, if possible, as they can affect the results. Typically, no other special preparations such as fasting are required. Disclose any medications you are currently taking to your healthcare provider.

Procedure Description

  1. The healthcare provider will clean the area around a vein in your arm.
  2. A needle is inserted into the vein to collect a blood sample.
  3. The blood sample is sent to a laboratory for analysis.

No special equipment or anesthesia is needed for this simple blood draw.


The blood draw itself only takes a few minutes. Results are usually available within a few days to a week, depending on the lab.


The procedure is typically performed in a hospital, outpatient clinic, or diagnostic lab.


A phlebotomist or nurse usually performs the blood draw. The analysis is conducted by a clinical laboratory technician.

Risks and Complications

  • Minor risks include bruising or discomfort at the needle site.
  • Rare risks might include infection where the needle was inserted or fainting.


Identifying abnormal Protein S levels can help establish a diagnosis for clotting disorders, potentially guiding effective treatment plans. Understanding these levels can prevent severe health incidents like stroke or deep vein thrombosis.


There is no recovery time needed for this blood test. After the blood draw, you can typically return to your normal activities immediately.


Other diagnostic tests for clotting disorders include Protein C tests, Antithrombin III tests, and clotting time assays. Each test has its own specific indications and may be used in conjunction with or as an alternative to the Protein S test.

Patient Experience

You might feel a small needle prick when the blood sample is taken. Some patients experience slight bruising or tenderness at the puncture site, but this generally resolves quickly.

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