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Clotting inhibitors or anticoagulants; protein C, activity

CPT4 code

Name of the Procedure:

Clotting Inhibitors or Anticoagulants; Protein C, Activity Assessment


The Protein C Activity test is a blood test used to measure the activity level of protein C, an important protein in the blood that helps regulate blood clotting. This procedure helps determine if there is a deficiency or abnormality with protein C, which can affect clotting.


The Protein C Activity test is used to diagnose and manage conditions that involve abnormal clotting, such as inherited protein C deficiency, which can lead to an increased risk of developing blood clots. The primary goal is to identify abnormalities in protein C levels to prevent and manage clotting disorders.


  • Unexplained blood clots
  • Family history of protein C deficiency or clotting disorders
  • Recurrent miscarriages
  • Screening before surgery in patients with a known history of clotting disorders


  • Fasting may not be required, but follow specific instructions provided by the healthcare provider.
  • Inform the healthcare provider about all medications, especially anticoagulants, as they may need to be temporarily adjusted.
  • No special diagnostic tests are generally required beforehand.

Procedure Description

  1. A healthcare professional will clean the skin where the blood will be drawn.
  2. An elastic band (tourniquet) is placed around the upper arm to fill the veins with blood.
  3. A needle is inserted into a vein, typically in the arm, to draw a blood sample.
  4. The blood sample is collected into a vial or test tube.
  5. The needle is removed, the site is cleaned, and a bandage is applied.
  6. The blood sample is sent to a laboratory for analysis to measure protein C activity.


The blood draw itself typically takes less than 5 minutes. Allow additional time for preparation and post-draw care.


The procedure is usually performed in a hospital, outpatient clinic, or specialized laboratory.


  • Phlebotomist or nurse for the blood draw
  • Laboratory technician or pathologist for the analysis

Risks and Complications

  • Minimal risk, primarily from the blood draw, such as:
    • Bruising
    • Discomfort at the needle insertion site
    • Fainting or dizziness
    • Rarely, infection at the puncture site


  • Accurate diagnosis of protein C deficiency or abnormalities
  • Informed decision-making for managing clotting disorders
  • Prevention of potential clotting complications Results are typically available within a few days to a week, allowing for timely intervention.


  • Minimal recovery needed after the blood draw
  • Patients can usually resume normal activities immediately
  • Keep the puncture site clean and monitor for signs of infection


  • Other blood tests to measure different clotting factors
  • Genetic testing for inherited clotting disorders
  • Imaging tests if clots are suspected but the exact clotting abnormality is unknown

Patient Experience

During the procedure, patients might experience a brief pinch or stinging sensation from the needle insertion. After the blood draw, there may be slight bruising or soreness at the puncture site. Overall, it is a quick and relatively painless procedure with minimal discomfort. Pain management is generally not necessary beyond simple over-the-counter remedies if needed.

Medical Policies and Guidelines for Clotting inhibitors or anticoagulants; protein C, activity

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