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Thromboplastin inhibition, tissue

CPT4 code

Name of the Procedure:

Thromboplastin Inhibition, Tissue
Common Name: Tissue Factor Inhibition Test


Thromboplastin inhibition, tissue, is a lab procedure that measures the time it takes for blood to clot by testing the inhibition of tissue thromboplastin, a protein crucial for blood clotting. This test helps diagnose and manage blood clotting disorders.


This procedure is primarily used to:

  • Diagnose bleeding disorders such as hemophilia.
  • Monitor anticoagulant therapy in patients.
  • Detect potential clotting issues pre-surgery. The main goal is to ensure proper blood clotting function and manage related disorders effectively.


  • Unexplained bleeding or bruising.
  • A family history of bleeding disorders.
  • Prior to surgery or invasive procedures to evaluate clotting ability.
  • Monitoring anticoagulant therapy efficiency, e.g., in conditions like deep vein thrombosis.


  • Patients may need to fast for a few hours before the test.
  • Certain medications, such as anticoagulants, might need to be paused.
  • Inform your doctor about any medications or supplements you're taking.

Procedure Description

  1. A blood sample is drawn from the patient, usually from a vein in the arm.
  2. The sample is mixed with an inhibitor of tissue thromboplastin in a lab.
  3. The time it takes for the blood to clot is measured. This involves standard venipuncture tools and laboratory equipment for the coagulation test. No anesthesia is required.


The blood draw takes approximately 5–10 minutes. The lab analysis may take a few hours to a day, depending on the facility.


The blood draw is performed in a hospital, outpatient clinic, or lab. The analysis occurs in a specialized laboratory.


  • A phlebotomist or nurse draws the blood.
  • A laboratory technician or pathologist conducts the analysis.

Risks and Complications

  • Rare risks include infection or hematoma at the blood draw site.
  • Potential for fainting or lightheadedness.
  • Complications from stopping certain medications may occur; consult your doctor.


  • Accurate diagnosis and management of clotting disorders.
  • Helps tailor anticoagulant therapy.
  • Crucial for safe surgical planning. Benefits can typically be realized shortly after test results are available, leading to appropriate medical interventions.


  • Minimal recovery needed; patients can resume normal activities immediately.
  • If a bruise forms at the blood draw site, apply a cold pack to reduce discomfort.
  • Follow up with your doctor to discuss the results and any necessary treatment plans.


  • Prothrombin Time (PT) test: Measures clotting time without the specific focus on tissue thromboplastin.
  • Activated Partial Thromboplastin Time (aPTT) test: Evaluates different clotting factors. Pros and cons vary; alternatives can be less specific but can offer additional insights into overall clotting function.

Patient Experience

  • Slight discomfort or a pinch when the needle is inserted.
  • Possible bruising or soreness at the draw site.
  • Comfort measures include bandaging the site and resting if feeling lightheaded.

Proper pain management and care are minimal due to the non-invasive nature of the sample collection.

Medical Policies and Guidelines for Thromboplastin inhibition, tissue

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