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Clotting inhibitors or anticoagulants; protein C, antigen

CPT4 code

Name of the Procedure:

Clotting Inhibitors or Anticoagulants; Protein C, Antigen Test


The Protein C, Antigen Test is a blood test used to measure the levels of protein C, which is a natural anticoagulant that helps regulate blood clot formation. This test provides important information about a person's blood clotting abilities.


The Protein C, Antigen Test is used to diagnose conditions related to abnormal blood clotting. It helps determine if a patient has a deficiency in protein C, which can lead to increased risk of blood clots and conditions like deep vein thrombosis or pulmonary embolism. The goal is to identify and manage clotting disorders to prevent complications.


  • Symptoms of unexplained blood clots.
  • Family history of clotting disorders.
  • Recurrent miscarriages.
  • Unusually high levels of blood clots.
  • Screening before certain surgeries or medical treatments.


  • Patients may be required to fast for a few hours before the test.
  • Avoid taking anticoagulant medications unless directed otherwise by a healthcare professional.
  • Inform the healthcare provider of any medications or supplements being taken.

Procedure Description

  1. A healthcare provider will clean the skin where the blood sample will be taken.
  2. A tourniquet is applied to the upper arm to make veins more visible.
  3. Using a sterile needle, blood is drawn from a vein, usually in the arm.
  4. The blood sample is collected in a vial or tube.
  5. The sample is sent to a laboratory for analysis.


The blood draw itself typically takes about 5 to 10 minutes, but the overall appointment may take around 30 minutes.


The test is usually performed in a hospital laboratory, outpatient clinic, or a specialized diagnostic center.


  • A phlebotomist or nurse will draw the blood sample.
  • A medical laboratory technologist will analyze the sample.
  • A physician or hematologist will interpret the results.

Risks and Complications

  • Minor bruising at the needle site.
  • Slight bleeding or infection at the puncture site (rare).
  • Fainting or feeling lightheaded (infrequent).


  • Helps diagnose protein C deficiency and other clotting disorders.
  • Aids in the prevention and management of serious clotting events.
  • Provides crucial information for creating a tailored treatment plan.


  • Minimal recovery time is needed.
  • Patients may resume normal activities immediately.
  • Keep the puncture site clean and follow the provider’s instructions.


  • Genetic tests for clotting disorders.
  • Screening for other clotting factors such as Factor V Leiden.
  • Assessment of family medical history.
  • Other blood tests that evaluate the entire clotting cascade.

Patient Experience

  • Patients may experience a small prick when the needle is inserted.
  • Minimal discomfort afterward; a small bandage may be applied.
  • Pain is typically mild and temporary.
  • Communication with the healthcare provider helps minimize anxiety and ensure comfort.

Medical Policies and Guidelines for Clotting inhibitors or anticoagulants; protein C, antigen

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