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Clotting; factor XIII (fibrin stabilizing)

CPT4 code

Name of the Procedure:

Clotting; Factor XIII (Fibrin Stabilizing) Common Name: Factor XIII Assay, Fibrin Stabilizing Factor Test


Factor XIII (Fibrin Stabilizing) testing is a blood test used to determine the activity level of Factor XIII, a crucial protein for blood clot stability. This test helps diagnose factor XIII deficiency, which can lead to bleeding disorders.


The primary purpose of the Factor XIII test is to detect deficiencies or abnormalities in Factor XIII, which can result in inadequate blood clot formation. This is vital for diagnosing potential bleeding disorders and guiding appropriate treatment options.


  • Unexplained bleeding or bruising
  • Abnormal postoperative bleeding
  • Recurrent pregnancy loss
  • Family history of clotting disorders
  • Pre-surgical evaluations, particularly if there is a history of bleeding disorders


  • Fasting may not be required.
  • Inform the healthcare provider of any medications, particularly anticoagulants.
  • A routine blood sample will be drawn, so ensure that the patient is hydrated and calm.

Procedure Description

  1. A blood sample is collected from a vein in the arm using a sterile needle.
  2. The sample is sent to a laboratory for analysis.
  3. Laboratory technicians perform a Factor XIII assay to determine the activity level of the factor. Tools: Sterile needle, collection tube. No anesthesia or sedation is typically needed for the blood draw.


The blood draw itself takes around 5-10 minutes. Laboratory analysis can take several hours to a few days, depending on the facility.


The blood sample collection is typically performed in a hospital, outpatient clinic, or a diagnostic laboratory.


  • Phlebotomist for blood draw
  • Laboratory technician for the assay
  • Hematologist or physician for interpretation of results

Risks and Complications

  • Minor discomfort or bruising at the puncture site
  • Rarely, infection at the puncture site
  • Fainting or feeling light-headed during or after the blood draw


  • Accurate diagnosis of Factor XIII deficiency or related clotting disorders
  • Timely intervention and appropriate treatment
  • Improved management of bleeding risks, especially during surgeries or childbirth


  • Patients can resume normal activities immediately after the blood draw.
  • Follow any specific instructions provided by the healthcare provider based on results.


  • Other clotting factor assays (e.g., Factor VIII, Factor IX)
  • Genetic testing if hereditary clotting disorder is suspected
  • Thromboelastography to assess clot formation and stability

Patient Experience

The patient may feel a slight prick when the needle is inserted and minor discomfort if the needle site bruises. Post-procedural pain is minimal, and patients are encouraged to stay hydrated and avoid strenuous activities for the remainder of the day.

Pain management is typically not needed, but over-the-counter pain relievers can ease any mild post-procedural discomfort.

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