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Injection, ofatumumab, 10 mg

HCPCS code

Name of the Procedure:

Common Name(s): Injection of Ofatumumab
Technical/Medical Term: Intravenous Injection of Ofatumumab, 10 mg


This procedure involves administering an injection of ofatumumab, a medication used for certain medical conditions, directly into the bloodstream.


Medical Conditions: Primarily used to treat specific types of blood cancers, such as chronic lymphocytic leukemia (CLL).
Goals: The aim is to target and destroy malignant cells, reduce tumor size, achieve remission, and relieve symptoms related to the disease.


Symptoms/Conditions: Persistent or aggressive chronic lymphocytic leukemia that has not responded to other treatments.
Patient Criteria: Patients with confirmed chronic lymphocytic leukemia, particularly those with specific genetic markers or who have not benefited from previous therapies.


Pre-procedure Instructions:

  • Fasting may be required for a few hours before the procedure, as advised by the medical team.
  • Medication adjustments: Patients might need to stop certain medications or supplements beforehand; always consult with your healthcare provider. Diagnostic Tests: Blood tests and imaging studies to confirm eligibility and assess the overall health status.

Procedure Description

  1. Preparation of the Injection Site: The area where the injection will be administered is typically cleaned and disinfected.
  2. Insertion of IV Line: An intravenous (IV) line is inserted into a vein in the patient's arm.
  3. Administration of Medication: Ofatumumab is slowly injected through the IV line. This process allows the medication to enter the bloodstream directly. Tools/Equipment: IV line, syringe, ofatumumab medication. Anesthesia/Sedation: Not typically required, but local anesthesia may be applied to the injection site if necessary.


Typical Time: The injection process can take 30 minutes to several hours, depending on the dosage and the patient's response.


Location: Usually performed in a hospital or outpatient clinic.


Healthcare Professionals:

  • Oncologist/Hematologist: Manages and oversees the treatment plan.
  • Nurse: Administers the injection and monitors the patient during the procedure.
  • Pharmacist: Prepares and verifies the medication dosage.

Risks and Complications

Common Risks:

  • Allergic reactions at the injection site, such as redness, swelling, or itching.
  • Flu-like symptoms, including fever, chills, and fatigue. Rare Risks:
  • Severe allergic reactions (anaphylaxis).
  • Infection at the injection site.
  • Drop in blood cell counts, leading to increased risk of infection or bleeding. Management: Close monitoring during and after the procedure, with emergency protocols in place for severe reactions.


Expected Benefits:

  • Reduced tumor size.
  • Long-term remission of leukemia.
  • Symptom relief. Timeframe: Benefits may be observed within a few weeks to months after starting treatment.


Post-procedure Care:

  • Monitor for any immediate adverse reactions.
  • Regular follow-up appointments to monitor progress and manage side effects. Expected Recovery Time: Patients may resume normal activities within a day or two, depending on their overall health and response to the treatment.


Other Treatment Options:

  • Chemotherapy.
  • Radiation therapy.
  • Bone marrow transplant. Pros and Cons:
  • Chemotherapy: Can also target cancer cells but has more systemic side effects.
  • Radiation: Localized treatment, but may not be suitable for widespread disease.
  • Bone marrow transplant: Potentially curative, but comes with higher risks and longer recovery.

Patient Experience

During the Procedure:

  • Mild discomfort during IV insertion.
  • Possible sensations of coolness or mild burning at the injection site. After the Procedure:
  • Fatigue and flu-like symptoms may occur.
  • Pain management with over-the-counter pain relievers if needed.
  • Comfort measures such as rest and hydration.

Patients are encouraged to communicate any discomfort or side effects to their healthcare provider promptly.

Medical Policies and Guidelines for Injection, ofatumumab, 10 mg

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Arzerra (ofatumumab)

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