Injection, Bendamustine HCL (Bendeka), 1 mg (J9034)

Name of the Procedure:

Common name(s):

• Bendamustine Injection
  Medical term(s):
• Bendeka, Bendamustine Hydrochloride Injection

Summary

Bendamustine HCL (Bendeka) Injection is a chemotherapy treatment used to treat certain types of cancers. Administered through an IV, this medication helps control cancer cell growth by interfering with their DNA function.

Purpose

Bendeka is primarily used to treat various forms of lymphoma (such as non-Hodgkin’s lymphoma) and chronic lymphocytic leukemia (CLL). The goal is to inhibit cancer cell proliferation, induce cancer cell death, and ultimately improve survival rates and quality of life.

Indications

• Non-Hodgkin's lymphoma
• Chronic lymphocytic leukemia (CLL)
• Patients who have not responded to other treatment regimens or whose disease has relapsed.

Preparation

• Patients may need to undergo blood tests to assess liver and kidney function.
• Fasting or specific dietary restrictions may not be required, but it’s important to follow your healthcare provider’s instructions.
• List any medications, supplements, or allergies to your healthcare provider.
• Stay well-hydrated before the procedure as per your healthcare provider’s advice.

Procedure Description

1. Pre-administration: Assessment and confirmation of patient identity, administration site, and dosage calculation.
2. Administration: An IV line is inserted into the vein, and Bendeka is administered over 10 minutes.
3. Monitoring: Vital signs are monitored during and after the infusion to detect any adverse reactions.

Tools, equipment, and technology used:

• IV line and administration set
• Bendamustine HCL (Bendeka) solution
• Infusion pump (optional)

Anesthesia or sedation details:

• Not typically required.

Duration

The IV infusion lasts approximately 10 minutes, but the entire appointment may take longer, including preparation and monitoring time.

Setting

• Outpatient clinic
• Oncology treatment center
• Hospital

Personnel

• Oncologist
• Oncology nurse or infusion nurse
• Possibly a pharmacist for medication preparation

Risks and Complications

Common risks:

• Infusion reactions (fever, chills, itching)
• Nausea, vomiting
• Fatigue
• Low blood cell counts (anemia, neutropenia, thrombocytopenia)

Rare risks:

• Severe allergic reactions
• Infections due to lowered immunity
• Tumor lysis syndrome (rapid breakdown of cancer cells)

Benefits

• Potential control and reduction of cancer cell growth
• Symptom relief and extended disease-free intervals
• Improvement in the overall quality of life

Expected benefits can start to become apparent after several treatment cycles, varying per individual.

Recovery

• Monitor for side effects and report any adverse reactions to your healthcare provider.
• Follow-up appointments for blood tests and assessment.
• Rest and hydrate well post-procedure.
• Restrictions may involve avoiding crowded places or infections due to reduced immunity.

Expected recovery time varies but adjustments to activity levels may be needed during treatment cycles.

Alternatives

• Other chemotherapy agents
• Radiation therapy
• Stem cell transplant
• Targeted therapy

Each alternative has its pros and cons depending on the specific cancer type, progression, and individual patient factors.

Patient Experience

During the procedure, patients might feel a slight pinch from the IV insertion. Post-procedure, patients could experience fatigue, nausea, and other mild side effects. Pain management and anti-nausea medications are often provided to ensure patient comfort.