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Hemolysins and agglutinins; auto, screen, each

CPT4 code

Name of the Procedure:

Hemolysins and Agglutinins; Auto, Screen, Each


The Hemolysins and Agglutinins auto screen is a blood test used to detect the presence of autoantibodies in a patient's blood. These autoantibodies can cause the destruction of the patient's own red blood cells, leading to conditions such as autoimmune hemolytic anemia.


This test is conducted to identify autoimmune conditions that cause the body to produce antibodies against its own red blood cells. The primary goal is to diagnose and manage conditions like autoimmune hemolytic anemia, ensuring appropriate treatment and management.


  • Unexplained anemia
  • Fatigue and pallor (paleness)
  • Jaundice (yellowing of the skin)
  • Dark-colored urine
  • A known or suspected autoimmune disorder


  • No specific fasting or dietary restrictions are usually required.
  • Patients should inform their healthcare provider of any medications they are taking, as some drugs can affect the results.
  • A simple blood draw is required for the test.

Procedure Description

  1. Blood Sample Collection: A healthcare professional will draw a blood sample from a vein, typically in the arm.
  2. Laboratory Analysis: The blood sample is sent to a laboratory where it is tested for the presence of autoantibodies that react with red blood cells.
  3. Results Interpretation: The results are analyzed by a pathologist or a specialist, who will report the findings to the referring healthcare provider.


The blood draw itself takes around 5-10 minutes. Laboratory analysis and result reporting can vary, generally taking a few days.


  • Outpatient clinic
  • Hospital laboratory
  • Specialized diagnostic centers


  • Phlebotomist or nurse for blood draw
  • Laboratory technicians and pathologists for sample analysis
  • Healthcare provider to discuss results and next steps

Risks and Complications

  • Minor pain, bruising, or bleeding at the blood draw site
  • Rare risk of infection


  • Accurate diagnosis of autoimmune hemolytic anemia and other related conditions
  • Helps guide appropriate treatment, improving patient outcomes
  • Early detection can lead to better management of symptoms and prevention of complications


  • Minimal recovery time; patients can resume normal activities immediately after the blood draw.
  • Follow-up appointments may be necessary to discuss results and treatment options.


  • Direct Antiglobulin Test (Coombs test)
  • Peripheral blood smear
  • Comprehensive metabolic panel
  • Consultation with a hematologist for further evaluation

Patient Experience

  • The blood draw procedure is quick and may involve slight discomfort akin to a pinch.
  • Post-procedure, any discomfort or bruising typically resolves within a couple of days.
  • If feeling anxious about the procedure, patients can discuss pain management or relaxation techniques with their healthcare provider.

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