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Antibody; Coccidioides

CPT4 code

Name of the Procedure:

Antibody Test for Coccidioides (Coccidioides Serology)


An Antibody Test for Coccidioides is a blood test that detects antibodies to the fungus Coccidioides immitis, which causes coccidioidomycosis or Valley Fever. The test helps determine if a person has a current or past infection with this fungus.


The test primarily addresses concerns related to potential fungal infections caused by Coccidioides. Its goal is to identify an active or previous infection and to help guide appropriate treatment.


  • Persistent cough, chest pain, and fever without a clear cause.
  • History of travel to areas where Coccidioides is common (e.g., southwestern United States).
  • Symptoms like fatigue and night sweats that suggest a fungal infection.
  • Immunocompromised patients with unexplained respiratory symptoms.


  • No special preparation is required for the antibody test.
  • Patients should inform their healthcare provider about any medications they’re taking as certain conditions might require consideration.

Procedure Description

  1. A healthcare professional will clean the puncture site on the patient's arm.
  2. A needle is inserted into a vein, and a blood sample is drawn into a vial or tube.
  3. The blood sample is sent to a laboratory for analysis.
  4. The lab uses specific tests to detect antibodies to Coccidioides in the blood.


The blood draw itself takes about 5 to 10 minutes. Results are typically available in a few days to a week.


The procedure is performed in a hospital, outpatient clinic, or lab.


A phlebotomist or nurse collects the blood sample, and a laboratory technician analyzes it.

Risks and Complications

  • Minor bruising or bleeding at the puncture site.
  • Slight risk of infection.
  • Rarely, patients might feel lightheaded or faint.


  • Provides a diagnosis of Coccidioides infection, aiding in targeted treatment.
  • Helps rule out other causes of symptoms.
  • Early detection can prevent serious complications.


  • No specific recovery time is needed.
  • Patients can resume normal activities immediately post-procedure.
  • Follow-up appointments may be necessary to discuss results and treatment plans.


  • Sputum culture or tissue biopsy could be considered to identify the fungus directly.
  • Radiological imaging may be used to examine lung conditions.
  • Pros and cons: Sputum culture and biopsies are more invasive, while imaging only shows the physical state, not the presence of antibodies.

Patient Experience

  • Patients may feel a quick pinch during the needle insertion.
  • Any discomfort is usually brief and managed with basic comfort measures.
  • Overall, the procedure is minimally invasive and well-tolerated.