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Infectious agent antibody detection by rapid antibody test, hiv-1 and/or hiv-2, screening

HCPCS code

Name of the Procedure:

Rapid HIV Antibody Test
Technical Term: Infectious Agent Antibody Detection by Rapid Antibody Test, HIV-1 and/or HIV-2, Screening (HCPCS Code G0435)


This test is a quick and straightforward method to detect antibodies for HIV-1 and HIV-2, the two main types of the Human Immunodeficiency Virus (HIV). The test provides results rapidly, usually within 20 to 30 minutes, using a small blood sample.


Medical Conditions Addressed
  • Detects HIV-1 and/or HIV-2 infections.
  • Early identification of HIV infection.
  • Facilitating prompt linkage to care and treatment.


Symptoms or Conditions
  • Unexplained fever, swollen lymph nodes, persistent fatigue, and other general signs of infection.
  • High-risk behaviors (e.g., unprotected sex, intravenous drug use).
  • Pregnant women as part of routine prenatal care.
  • Individuals with known exposure to HIV.
Patient Criteria
  • Anyone seeking HIV screening for peace of mind or due to potential exposure.


  • No fasting required.
  • Ensure all relevant medical history and current medications are disclosed.
  • Inform the healthcare provider of any recent illnesses that might affect test results.

Procedure Description

  1. Sample Collection: A small blood sample is collected using a lancet to prick the fingertip or a small venous sample.
  2. Application to Test Device: The blood sample is applied to a test strip or cassette.
  3. Waiting Period: The test requires a short waiting period, typically 20-30 minutes.
  4. Result Interpretation: The test result is displayed on the device, indicating either a positive, negative, or indeterminate result.
Tools and Equipment
  • Lancet or needle for blood collection.
  • Rapid antibody testing device (strip or cassette).
Anesthesia or Sedation
  • Not required, as the procedure is minimally invasive.


  • Generally takes about 30 minutes from sample collection to result delivery.


  • Can be performed in various settings including hospitals, outpatient clinics, community health centers, and even mobile testing units.


  • Typically administered by trained healthcare professionals such as nurses, physicians, or trained community health workers.

Risks and Complications

Common Risks
  • Minor pain or bruising at the site of blood collection.

    Rare Risks
  • Very rare chances of incorrect results (false positives or false negatives).

Complications Management
  • Indeterminate or unexpected results should be followed up with a confirmatory lab-based test.


Expected Benefits
  • Rapid and early detection of HIV.
  • Immediate counseling and support for positive individuals.
  • Helps reduce the spread of HIV through early diagnosis.
Realization Time
  • Benefits are realized immediately upon receiving the test result.


  • No specific recovery needed.
  • Patients who test positive will be advised on further diagnostic tests, treatment options, and preventive measures.
  • Usually resume normal activities immediately.


Other Treatment Options
  • Traditional lab-based blood tests for HIV.
Pros and Cons
  • Pros of Rapid Test: Quick results, convenient, and easy to administer.
  • Cons of Rapid Test: Slightly less sensitivity compared to lab-based tests.

    Patient Experience

    During the Procedure
  • Minor discomfort during blood collection.

After the Procedure
  • If negative, reassurance and peace of mind.
  • If positive, might experience anxiety but immediate counseling and support are provided.

    Pain Management and Comfort Measures
  • Minimal discomfort, typically requiring no significant pain management measures.

Medical Policies and Guidelines for Infectious agent antibody detection by rapid antibody test, hiv-1 and/or hiv-2, screening

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