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Syphilis test, non-treponemal antibody; quantitative

CPT4 code

Name of the Procedure:

Syphilis Test, Non-Treponemal Antibody; Quantitative
Common Name: VDRL Test, RPR Test
Medical Term: Venereal Disease Research Laboratory Test, Rapid Plasma Reagin Test


The syphilis test, non-treponemal antibody; quantitative, measures the amount of antibodies present in the blood that are produced as a response to the syphilis-causing bacterium, Treponema pallidum. It helps in diagnosing and monitoring the treatment of syphilis.


The syphilis test is used to diagnose an active syphilis infection and to monitor the effectiveness of treatment. It helps in ensuring that the infection is being adequately controlled.


  • Unexplained rashes or sores, particularly in the genital region
  • Symptoms consistent with syphilis, such as fever, swollen lymph nodes, or muscle aches
  • Positive treponemal screening test result
  • A partner diagnosed with syphilis
  • Routine prenatal screening in pregnant women
  • Monitoring of treatment progress in known syphilis patients


  • No specific preparation is typically required.
  • Inform your healthcare provider about any medications you are taking.
  • A simple blood draw is often scheduled, requiring no fasting or dietary changes.

Procedure Description

  1. A healthcare provider will clean the skin where the blood sample will be taken.
  2. An elastic band may be placed around your upper arm to fill the veins with blood.
  3. A sterile needle is used to draw blood from a vein in your arm.
  4. The blood sample is collected in a vial or tube.
  5. The sample is then sent to a lab for analysis.
  6. The lab will measure the concentration of non-treponemal antibodies.

Tools: Needles, blood collection tubes, antiseptic wipes.
Anesthesia: None required.


The blood draw takes about 5-10 minutes. Results are typically available within a few days.


The procedure is usually done in a hospital, outpatient clinic, or a specialized lab collection center.


  • Trained phlebotomist or nurse for blood draw.
  • Laboratory technicians for sample analysis.
  • Healthcare providers for interpreting the results.

Risks and Complications

  • Minor bruising or bleeding at the puncture site.
  • Rarely, infection at the puncture site.
  • Fainting or dizziness may occur but is uncommon.


  • Accurate detection and monitoring of syphilis.
  • Early diagnosis leads to timely treatment, reducing complications.
  • Monitoring helps ensure the effectiveness of the treatment regimen.


  • Minimal recovery time; patients can resume normal activities immediately.
  • Keep the puncture site clean and dry; apply a bandaid if necessary.
  • No restrictions or special follow-up required unless symptoms persist or worsen.


  • Treponemal antibody tests (e.g., FTA-ABS, TP-PA) for confirmation of the infection.
  • PCR tests to detect the genetic material of Treponema pallidum.
  • Clinical examination and symptom evaluation.

Patient Experience

  • Mild discomfort or a slight pinch when the needle is inserted.
  • Slight soreness or bruising at the puncture site.
  • Minimal pain or side effects following the procedure, easily managed with over-the-counter pain relief if necessary.

By providing detailed insights into this procedure, patients can better understand what to expect and how to prepare, contributing to a seamless diagnostic experience.

Medical Policies and Guidelines for Syphilis test, non-treponemal antibody; quantitative

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