Hyperbaric Oxygen Therapy Form
Please answer all questions to determine coverage (0 of 3)
500 EXCHANGE STREET, PROVIDENCE, RI 02903-2699
MEDICAL COVERAGE POLICY | 1
(401) 274-4848 WWW.BCBSRI.COM
EFFECTIVE DATE: 10|01|2019
POLICY LAST REVIEWED: 10|01|2025
OVERVIEW
Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen at pressures between 1.5 and 3.0
atmospheres. It is generally applied systemically with the patient inside a hyperbaric chamber. HBOT can also
be applied topically; ie, the body part to be treated is isolated (eg, in an inflatable bag and exposed to pure
oxygen). HBOT has been investigated for various conditions that have potential to respond to increased
oxygen delivery to tissue.
MEDICAL CRITERIA
Not applicable
PRIOR AUTHORIZATION
Not applicable
POLICY STATEMENT
Medicare Advantage Plans and Commercial Products
Hyperbaric oxygen therapy (HBOT) is medically necessary when filed with a covered indication.
Hyperbaric oxygen therapy (HBOT) is not covered for Medicare Advantage Plans and not medically
necessary for Commercial Products for all other indications as the evidence is insufficient to determine the
effects of the technology on health outcomes.
Medicare Advantage Plans
Topical hyperbaric oxygen therapy is not covered as the evidence is insufficient to determine the effects of
the technology on health outcomes.
Commercial Products
Topical hyperbaric oxygen therapy is not medically necessary as the evidence is insufficient to determine the
effects of the technology on health outcomes.
COVERAGE
Benefits may vary between groups/contracts. Please refer to the appropriate section of the Benefit Booklet,
Evidence of Coverage, Subscriber Agreement for applicable medical treatment coverage.
BACKGROUND
Hyperbaric Oxygen Therapy
Hyperbaric oxygen therapy (HBOT) is a technique for delivering higher pressures of oxygen to tissue. Two
methods of administration are available: topical and systemic.
Topical Hyperbaric Oxygen Therapy
Topical hyperbaric therapy is a technique of delivering 100% oxygen directly to an open, moist wound at a
pressure slightly higher than atmospheric pressure. It is hypothesized that the high concentrations of oxygen
diffuse directly into the wound to increase the local cellular oxygen tension, which in turn promotes wound
healing. Devices consist of an appliance to enclose the wound area (frequently an extremity) and a source of
oxygen; conventional oxygen tanks may be used. The appliances may be disposable and may be used without
supervision in the home by well-trained patients. Topical hyperbaric therapy has been investigated as a
treatment of skin ulcerations resulting from diabetes, venous stasis, postsurgical infection, gangrenous lesion,
decubitus ulcers, amputations, skin graft, burns, or frostbite.
Medical Coverage Policy | Hyperbaric Oxygen
Therapy
500 EXCHANGE STREET, PROVIDENCE, RI 02903-2699 MEDICAL COVERAGE POLICY | 2 (401) 274-4848 WWW.BCBSRI.COM
Systemic Hyperbaric Oxygen Therapy In systemic or large hyperbaric oxygen chambers, the patient is entirely enclosed in a pressure chamber and breathes oxygen at a pressure greater than 1 atmosphere (the pressure of oxygen at sea level). Thus, this technique relies on systemic circulation to deliver highly oxygenated blood to the target site, typically a wound. Systemic HBOT can be used to treat systemic illness, such as air or gas embolism, carbon monoxide poisoning, or clostridial gas gangrene. Treatment may be carried out either in a monoplace chamber pressurized with pure oxygen or in a larger, multiplace chamber pressurized with compressed air, in which case the patient receives pure oxygen by mask, head tent, or endotracheal tube.
The evidence for the use of systemic HBOT in individuals with nonhealing diabetic wounds of the lower extremities, acute traumatic ischemia, soft-tissue radiation necrosis (eg, radiation enteritis, cystitis, proctitis), osteoradionecrosis (ie, pre- and posttreatment), planned dental surgery (non-implant-related) of an irradiated jaw, gas gangrene, and profound anemia with exceptional blood loss when blood transfusion is impossible or must be delayed includes systematic reviews and/or recommendations from the Undersea and Hyperbaric Medical Society’s (UHMS). Relevant outcomes include overall survival, symptoms, change in disease status, and functional outcomes. For all indications in the PICO note, evidence and/or USMS guidelines support use of HBOT. The evidence is sufficient to determine qualitatively that the technology results in a meaningful improvement in health outcomes.
The evidence for the use of systemic HBOT in individuals with any condition other than those specified in the policy are not medically necessary as the available studies do not demonstrate that HBOT improves relevant outcomes. The evidence is insufficient to determine the effects of the technology on health outcomes.
The evidence for the use of topical HBOT in individuals who might respond to increased oxygen delivery to tissues includes primarily of case series and case reports. Relevant outcomes are symptoms and change in disease status. A systematic review identified 3 RCTs on the use of topical HBOT for chronic wound healing. The results showed topical oxygen therapy improved wound healing, but there was heterogeneity in the trial populations and treatment regimens. There is a small RCT on topical HBOT for diabetic foot ulcers; it showed no differences in outcomes between the treatment and control group. No controlled studies on topical HBOT for patients with burns or infections were identified. The data are insufficient to draw conclusions about the effect on the net health outcome.
CODING:
Medicare Advantage Plans and Commercial Products
The following code(s) are medically necessary when filed with a covered ICD-10 Diagnosis Code* listed
below:
99183 Physician or other qualified health care professional attendance and supervision of hyperbaric oxygen
therapy, per session
G0277 Hyperbaric oxygen under pressure, full body chamber, per 30 minute interval
Note: The covered diagnosis must be filed on the claim line to ensure correct claim processing
*2025 Covered Diagnosis Code List for Hyperbaric Oxygen Therapy
The following HCPCS code(s) are not covered for Medicare Advantage Plans and not medically necessary for Commercial Products: A4575 Topical hyperbaric oxygen chamber, disposable E0446 Topical oxygen delivery system, not otherwise specified, includes all supplies and accessories
RELATED POLICIES Not applicable
PUBLISHED
500 EXCHANGE STREET, PROVIDENCE, RI 02903-2699 MEDICAL COVERAGE POLICY | 3 (401) 274-4848 WWW.BCBSRI.COM
Provider Update, December 2025 Provider Update, October 2024 Provider Update, April 2023 Provider Update, April 2022 Provider Update, May 2021
REFERENCES
- Centers for Medicare and Medicaid Services (CMS). National Coverage Determination (NCD) for Hyperbaric Oxygen Therapy (20.29). 2017; https://www.cms.gov/medicare-coverage- database/details/ncd-details.aspx?ncdid=12&ver=3. Accessed July 10, 2024.
- The Centers for Medicare and Medicaid Services. Local Coverage Determination (LCD) for Oxygen and Oxygen Equipment (L33797): https://www.cms.gov/medicare-coverage- database/view/lcd.aspx?lcdid=33797&ver=50&bc=0
- Undersea and Hyperbaric Medical Society. Hyperbaric Oxygen Therapy Indications, 15th Edition. Best Publishing Company (North Palm Beach, FL). 2023.
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- Bennett MH, Feldmeier J, Hampson NB, et al. Hyperbaric oxygen therapy for late radiation tissue injury. Cochrane Database Syst Rev. Apr 28 2016; 4(4): CD005005. PMID 27123955
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- Maynor ML, Moon RE, Camporesi EM, et al. Chronic osteomyelitis of the tibia: treatment with hyperbaric oxygen and autogenous microsurgical muscle transplantation. J South Orthop Assoc. 1998; 7(1): 43-57. PMID 9570731
500 EXCHANGE STREET, PROVIDENCE, RI 02903-2699 MEDICAL COVERAGE POLICY | 4 (401) 274-4848 WWW.BCBSRI.COM
- Davis JC, Heckman JD, DeLee JC, et al. Chronic non-hematogenous osteomyelitis treated with adjuvant hyperbaric oxygen. J Bone Joint Surg Am. Oct 1986; 68(8): 1210-7. PMID 3771602
- Chen CE, Ko JY, Fu TH, et al. Results of chronic osteomyelitis of the femur treated with hyperbaric oxygen: a preliminary report. Chang Gung Med J. Feb 2004; 27(2): 91-7. PMID 15095953
- Chen CE, Shih ST, Fu TH, et al. Hyperbaric oxygen therapy in the treatment of chronic refractory osteomyelitis: a preliminary report. Chang Gung Med J. Feb 2003; 26(2): 114-21. PMID 12718388
- Chen CY, Lee SS, Chan YS, et al. Chronic refractory tibia osteomyelitis treated with adjuvent hyperbaric oxygen: a preliminary report. Changgeng Yi Xue Za Zhi. Jun 1998; 21(2): 165-71. PMID 9729650
- Villanueva E, Bennett MH, Wasiak J, et al. Hyperbaric oxygen therapy for thermal burns. Cochrane Database Syst Rev. 2004; 2004(3): CD004727. PMID 15266540
- Eskes A, Vermeulen H, Lucas C, et al. Hyperbaric oxygen therapy for treating acute surgical and traumatic wounds. Cochrane Database Syst Rev. Dec 16 2013; (12): CD008059. PMID 24343585
- Dauwe PB, Pulikkottil BJ, Lavery L, et al. Does hyperbaric oxygen therapy work in facilitating acute wound healing: a systematic review. Plast Reconstr Surg. Feb 2014; 133(2): 208e-215e. PMID 24469192
- Zhou YY, Liu W, Yang YJ, et al. Use of hyperbaric oxygen on flaps and grafts in China: analysis of studies in the past 20 years. Undersea Hyperb Med. 2014; 41(3): 209-16. PMID 24984315
- Freiberger JJ, Padilla-Burgos R, McGraw T, et al. What is the role of hyperbaric oxygen in the management of bisphosphonate-related osteonecrosis of the jaw: a randomized controlled trial of hyperbaric oxygen as an adjunct to surgery and antibiotics. J Oral Maxillofac Surg. Jul 2012; 70(7): 1573-
- PMID 22698292
- Levett D, Bennett MH, Millar I. Adjunctive hyperbaric oxygen for necrotizing fasciitis. Cochrane Database Syst Rev. Jan 15 2015; 1(1): CD007937. PMID 25879088
- Hedetoft M, Bennett MH, Hyldegaard O. Adjunctive hyperbaric oxygen treatment for necrotising soft- tissue infections: A systematic review and meta-analysis. Diving Hyperb Med. Mar 31 2021; 51(1): 34-43. PMID 33761539
- Bennett MH, Lehm JP, Jepson N. Hyperbaric oxygen therapy for acute coronary syndrome. Cochrane Database Syst Rev. Jul 23 2015; 2015(7): CD004818. PMID 26202854
- Bennett MH, Weibel S, Wasiak J, et al. Hyperbaric oxygen therapy for acute ischaemic stroke. Cochrane Database Syst Rev. Nov 12 2014; (11): CD004954. PMID 25387992
- Efrati S, Fishlev G, Bechor Y, et al. Hyperbaric oxygen induces late neuroplasticity in post stroke patients--randomized, prospective trial. PLoS One. 2013; 8(1): e53716. PMID 23335971
- Holland NJ, Bernstein JM, Hamilton JW. Hyperbaric oxygen therapy for Bell's palsy. Cochrane Database Syst Rev. Feb 15 2012; 2012(2): CD007288. PMID 22336830
- Wang F, Wang Y, Sun T, et al. Hyperbaric oxygen therapy for the treatment of traumatic brain injury: a meta-analysis. Neurol Sci. May 2016; 37(5): 693-701. PMID 26746238
- Crawford C, Teo L, Yang E, et al. Is Hyperbaric Oxygen Therapy Effective for Traumatic Brain Injury? A Rapid Evidence Assessment of the Literature and Recommendations for the Field. J Head Trauma Rehabil. 2017; 32(3): E27-E37. PMID 27603765
- Bennett MH, Trytko B, Jonker B. Hyperbaric oxygen therapy for the adjunctive treatment of traumatic brain injury. Cochrane Database Syst Rev. Dec 12 2012; 12: CD004609. PMID 23235612
- Hart BB, Weaver LK, Gupta A, et al. Hyperbaric oxygen for mTBI-associated PCS and PTSD: Pooled analysis of results from Department of Defense and other published studies. Undersea Hyperb Med. BIMA 2019; 46(3): 353-383. PMID 31394604
- mTBI mechanisms of action of HBO2 for persistent post-concussive symptoms. U.S. National Library of Medicine. ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01611194. Accessed April 28,
- Hart BB, Wilson SH, Churchill S, et al. Extended follow-up in a randomized trial of hyperbaric oxygen for persistent post-concussive symptoms. Undersea Hyperb Med. BIMA 2019; 46(3): 313-327. PMID 31394601
- Churchill S, Deru K, Weaver LK, et al. Adverse events and blinding in two randomized trials of hyperbaric oxygen for persistent post-concussive symptoms. Undersea Hyperb Med. BIMA 2019; 46(3): 331-340. PMID 31394602
- Weaver LK, Churchill S, Wilson SH, et al. A composite outcome for mild traumatic brain injury in trials of hyperbaric oxygen. Undersea Hyperb Med. BIMA 2019; 46(3): 341-352. PMID 31394603
500 EXCHANGE STREET, PROVIDENCE, RI 02903-2699 MEDICAL COVERAGE POLICY | 5 (401) 274-4848 WWW.BCBSRI.COM
- Hyperbaric oxygen therapy (HBO2) for persistent post-concussive symptoms after mild traumatic brain injury (mTBI) (HOPPS). U.S. National Library of Medicine. ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01306968. Updated September 5, 2014. Accessed April 28,
- McCurdy J, Siw KCK, Kandel R, et al. The Effectiveness and Safety of Hyperbaric Oxygen Therapy in Various Phenotypes of Inflammatory Bowel Disease: Systematic Review With Meta-analysis. Inflamm Bowel Dis. Mar 30 2022; 28(4): 611-621. PMID 34003289
- Dulai PS, Buckey JC, Raffals LE, et al. Hyperbaric oxygen therapy is well tolerated and effective for ulcerative colitis patients hospitalized for moderate-severe flares: a phase 2A pilot multi-center, randomized, double-blind, sham-controlled trial. Am J Gastroenterol. Oct 2018; 113(10): 1516-1523. PMID 29453383
- Dulai PS, Raffals LE, Hudesman D, et al. A phase 2B randomised trial of hyperbaric oxygen therapy for ulcerative colitis patients hospitalised for moderate to severe flares. Aliment Pharmacol Ther. Sep 2020; 52(6): 955-963. PMID 32745306
- Pagoldh M, Hultgren E, Arnell P, et al. Hyperbaric oxygen therapy does not improve the effects of standardized treatment in a severe attack of ulcerative colitis: a prospective randomized study. Scand J Gastroenterol. Sep 2013; 48(9): 1033-40. PMID 23879825
- Bennett MH, Kertesz T, Perleth M, et al. Hyperbaric oxygen for idiopathic sudden sensorineural hearing loss and tinnitus. Cochrane Database Syst Rev. Oct 17 2012; 10: CD004739. PMID 23076907
- Rhee TM, Hwang D, Lee JS, et al. Addition of Hyperbaric Oxygen Therapy vs Medical Therapy Alone for Idiopathic Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-analysis. JAMA Otolaryngol Head Neck Surg. Dec 01 2018; 144(12): 1153-1161. PMID 30267033
- Joshua TG, Ayub A, Wijesinghe P, et al. Hyperbaric Oxygen Therapy for Patients With Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-analysis. JAMA Otolaryngol Head Neck Surg. Jan 01 2022; 148(1): 5-11. PMID 34709348
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- Cavaliere M, De Luca P, Scarpa A, et al. Combination of Hyperbaric Oxygen Therapy and Oral Steroids for the Treatment of Sudden Sensorineural Hearing Loss: Early or Late?. Medicina (Kaunas). Oct 10 2022; 58(10). PMID 36295581
- Bennett M, Best TM, Babul S, et al. Hyperbaric oxygen therapy for delayed onset muscle soreness and closed soft tissue injury. Cochrane Database Syst Rev. Oct 19 2005; 2005(4): CD004713. PMID 16235376
- Xiong T, Chen H, Luo R, et al. Hyperbaric oxygen therapy for people with autism spectrum disorder (ASD). Cochrane Database Syst Rev. Oct 13 2016; 10(10): CD010922. PMID 27737490
- Sampanthavivat M, Singkhwa W, Chaiyakul T, et al. Hyperbaric oxygen in the treatment of childhood autism: a randomised controlled trial. Diving Hyperb Med. Sep 2012; 42(3): 128-33. PMID 22987458
- Rizzato A, D'Alessandro N, Berenci E, et al. Effect of mild hyperbaric oxygen therapy on children diagnosed with autism. Undersea Hyperb Med. 2018; 45(6): 639-645. PMID 31158930
- Lacey DJ, Stolfi A, Pilati LE. Effects of hyperbaric oxygen on motor function in children with cerebral palsy. Ann Neurol. Nov 2012; 72(5): 695-703. PMID 23071074
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- Xiao Y, Wang J, Jiang S, et al. Hyperbaric oxygen therapy for vascular dementia. Cochrane Database Syst Rev. Jul 11 2012; (7): CD009425. PMID 22786527
- Villeirs L, Tailly T, Ost P, et al. Hyperbaric oxygen therapy for radiation cystitis after pelvic radiotherapy: Systematic review of the recent literature. Int J Urol. Feb 2020; 27(2): 98-107. PMID 31617263
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500 EXCHANGE STREET, PROVIDENCE, RI 02903-2699 MEDICAL COVERAGE POLICY | 6 (401) 274-4848 WWW.BCBSRI.COM
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- Efrati S, Golan H, Bechor Y, et al. Hyperbaric oxygen therapy can diminish fibromyalgia syndrome-- prospective clinical trial. PLoS One. 2015; 10(5): e0127012. PMID 26010952
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- Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. Dec 2019; 50(12): e344-e418. PMID 31662037
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Chandrasekhar SS, Tsai Do BS, Schwartz SR, et al. Clinical Practice Guideline: Sudden Hearing Loss (Update). Otolaryngol Head Neck Surg. Aug 2019; 161(1_suppl): S1-S45. PMID 31369359
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