T88.7XXS Unspecified adverse effect of drug or medicament, sequela

ICD-10-CM T88.7XXS: Unspecified adverse effect of drug or medicament, sequela

ICD-10-CM code T88.7XXS identifies a sequela of an unspecified adverse effect of a drug or medicament. The code is active and falls under the parent category T88.7. While medicines can cause unwanted reactions like side effects and allergies, this specific code is excluded from certain CMS reporting lists. 1 4 5

Plain-language overview

Code T88.7XXS is an active terminology concept representing an unspecified adverse effect of a drug or medicament, sequela, and it is classified under the semantic type of Injury or Poisoning. 1

What this code represents

The code T88.7XXS represents a sequela of an unspecified adverse effect of a drug or medicament, functioning as a narrower concept under the parent code T88.7. 1

Clinical context

During clinical drug development, a drug candidate's pharmacological effect may result from inhibiting unknown molecular targets, which can impact both efficacy and toxicity profiles. 2

An ideal drug candidate aims for high potency and specificity to inhibit its molecular target without off-target effects, minimizing drug exposure in healthy tissues to avoid toxicity. 2

Documentation considerations

The terminology record for T88.7XXS includes a published abbreviation matching its preferred name, which is Unspecified adverse effect of drug or medicament, sequela. 1

Coverage and utilization context

The Centers for Medicare and Medicaid Services added T88.7XXS to a list of unspecified complication codes excluded from reporting, distinguishing it from initial and subsequent encounter codes. 4

What the sources add

While the National Cancer Institute terminology record establishes the active status and parent hierarchy of T88.7XXS, the CMS exclusion list provides operational context regarding its reporting limitations. 1 4

The EVS Explore portal confirms the exact code T88.7XXS and its preferred name, aligning with the National Cancer Institute's official terminology record for this specific sequela diagnosis. 1 3

Sources

1. ICD-10-CM T88.7XXS terminology record — National Cancer Institute Enterprise Vocabulary Services; accessed 2026-07-27.
2. Why 90% of clinical drug development fails and how to improve it? — pmc.ncbi.nlm.nih.gov; accessed 2026-07-27.
3. EVS Explore — evsexplore.semantics.cancer.gov; accessed 2026-07-27.
4. News: CMS adds certain ICD-10-CM complication codes to 2017 excluded list — acdis.org; accessed 2026-07-27.
5. T88.7XXS — Unspecified adverse effect of drug or medicament, sequela | ICD-10 Code · Eleplan — eleplan.com; accessed 2026-07-27.