T43.224D Poisoning by selective serotonin reuptake inhibitors, undetermined, subsequent encounter

ICD-10-CM T43.224D: Poisoning by selective serotonin reuptake inhibitors, undetermined, subsequent encounter

ICD-10-CM code T43.224D identifies a subsequent encounter for poisoning by selective serotonin reuptake inhibitors where the intent is undetermined. The code appears in official CMS billing and coding articles and cancer.gov terminology resources. It is distinct from initial encounter and sequela codes, and it is listed alongside other SSRI poisoning intent codes. 1 3 4

Plain-language overview

Code T43.224D is labeled as poisoning by selective serotonin reuptake inhibitors, undetermined, subsequent encounter in the cited sources. It is listed in an official CMS billing article and an official terminology explorer. 1 3

What this code represents

The code represents a subsequent encounter for SSRI poisoning with undetermined intent. The seventh character D distinguishes it from the initial encounter code T43.224A and the sequela code T43.224S. 4

Coding details

T43.224D belongs to the category T43.224, poisoning by selective serotonin reuptake inhibitors, undetermined. Sibling codes in the same hierarchy include accidental, intentional self-harm, assault, and adverse effect codes. 4

Documentation considerations

The cited excerpts list T43.224D with its full official label and surrounding code-tree entries. They do not state specific documentation elements that must accompany this code. 1 4

Coverage and utilization context

A CMS billing and coding article includes T43.224D in a list of ICD-10-CM codes. The cited excerpt does not state coverage criteria or payment rules tied to this code. 1

What the sources add

The CMS controlled-substance article lists T43.224D by its official label, while the cancer.gov terminology explorer lists the same code and label. Both sources confirm the code exists in official references. 1 3

The Unbound Medicine source places T43.224D within a code tree showing adjacent SSRI codes such as T43.221D for accidental and T43.222D for intentional self-harm. The CMS article lists the code without showing this hierarchy. 1 4

Questions to verify

The CMS urine drug testing article lists an initial-encounter SSRI poisoning code and other antidepressant poisoning codes. The cited excerpt does not include T43.224D in that list. 2

Sources

1. Article - Billing and Coding: Controlled Substance Monitoring and Drugs of Abuse Testing (A56645) — cms.gov; accessed 2026-07-25.
2. Article - Billing and Coding: Urine Drug Testing (A56915) — cms.gov; accessed 2026-07-25.
3. EVS Explore — evsexplore.semantics.cancer.gov; accessed 2026-07-25.
4. ICD-10-CM 2024 | T43.22 - Poisoning by, adverse effect of and underdosing of selective serotonin reuptake inhibitors — unboundmedicine.com; accessed 2026-07-25.