T43.215S Adverse effect of selective serotonin and norepinephrine reuptake inhibitors, sequela

ICD-10-CM T43.215S: Adverse effect of selective serotonin and norepinephrine reuptake inhibitors, sequela

ICD-10-CM code T43.215S represents the sequela of an adverse effect of selective serotonin and norepinephrine reuptake inhibitors. The terminology record is active and classifies this concept under the semantic type of injury or poisoning. Serotonin-norepinephrine reuptake inhibitors prolong monoamine effects in the central nervous system. 1 2

Plain-language overview

Code T43.215S identifies a sequela associated with an adverse effect of selective serotonin and norepinephrine reuptake inhibitors, classified under the semantic type of injury or poisoning. 1

What this code represents

The official label for T43.215S is adverse effect of selective serotonin and norepinephrine reuptake inhibitors, sequela, and the concept carries the semantic type of injury or poisoning. 1

T43.215S is a narrower concept nested under the parent code T43.215, which denotes the adverse effect of selective serotonin and norepinephrine reuptake inhibitors. 1

Clinical context

Serotonin-norepinephrine reuptake inhibitors function by inhibiting presynaptic neuronal uptake, which prolongs monoamine presence in the synaptic cleft and increases postsynaptic receptor activation. 2

Five serotonin-norepinephrine reuptake inhibitors are currently marketed in the United States, specifically desvenlafaxine, duloxetine, levomilnacipran, milnacipran, and sibutramine. 2

Coding details

The terminology record for T43.215S is active for the 2026 version of ICD-10-CM and includes the published abbreviation for adverse effect of slctv seroton/norepineph reup inhibtr, sqla. 1

Documentation considerations

The supplied terminology record establishes the code's official title and active status, but the excerpts do not provide the specific clinical documentation elements needed to support coding a sequela for this diagnosis. 1

Coverage and utilization context

A Medicare billing and coding article references T43.215S within a broader list of diagnosis codes, distinguishing it from codes for selective serotonin reuptake inhibitors. 3

What the sources add

The Medicare article establishes that T43.215S appears in payer billing contexts, whereas the terminology record confirms its official status and parent code relationship without addressing coverage. 1 3

Sources

1. ICD-10-CM T43.215S terminology record — National Cancer Institute Enterprise Vocabulary Services; accessed 2026-07-27.
2. New Serotonin-Norepinephrine Reuptake Inhibitors and Their Anesthetic and Analgesic Considerations — pmc.ncbi.nlm.nih.gov; accessed 2026-07-27.
3. Article - Billing and Coding: RAST Type Tests (A56844) — cms.gov; accessed 2026-07-27.