P04.6 Newborn affected by maternal exposure to environmental chemical substances

ICD-10-CM Diagnosis Code P04.6: Newborn affected by maternal exposure to environmental chemical substances

ICD-10-CM code P04.6 identifies a newborn affected by maternal exposure to environmental chemical substances. This diagnosis falls under the broader category of newborns affected by noxious substances transmitted via placenta or breast milk. Environmental chemicals can cross the placenta, and postnatal maternal exposure may continue to affect a newborn through breastfeeding. 1 2 5

Plain-language overview

Code P04.6 describes a newborn affected by maternal exposure to environmental chemical substances, representing a specific finding rather than a general disease state. 1

Environmental chemicals can cross the placenta during pregnancy, and postnatal maternal exposure to these substances may continue to expose a newborn through breastfeeding. 2

What this code represents

Within the ICD-10-CM system, P04.6 is an active terminology concept classified under the parent code P04 for newborns affected by noxious substances transmitted via placenta or breast milk. 1

The P04 category includes distinct codes for various maternal noxious exposures, such as P04.5 for nutritional chemical substances and P04.8 for other specified maternal noxious substances. 5

Coding details

The official preferred name for P04.6 in the ICD-10-CM terminology record is newborn affected by maternal exposure to environmental chemical substances, and it carries the semantic type of finding. 1

While the CMS manual lists newborns affected by maternal exposure to environmental chemical substances, the WHO ICD-10 browser labels the equivalent concept as fetus and newborn affected by maternal exposure to environmental chemical substances. 3 4

Documentation considerations

The ICD-10-CM terminology record for P04.6 includes a published abbreviation, newborn aff by maternal exposure to environ chemical substnc, for the concept. 1

What the sources add

The P04 category is part of the P00-P04 block detailing fetuses and newborns affected by maternal factors and complications of pregnancy, labor, and delivery. 5 6

Scientific literature indicates that preconception and prenatal exposure to environmental chemicals can have a profound and lasting impact on health across the life course of the developing individual. 2

Sources

1. ICD-10-CM P04.6 terminology record — National Cancer Institute Enterprise Vocabulary Services; accessed 2026-07-27.
2. Toxic Environmental Chemicals: The Role of Reproductive Health Professionals In Preventing Harmful Exposures — pmc.ncbi.nlm.nih.gov; accessed 2026-07-27.
3. ICD-10-CM/PCS MS-DRGv33 Definitions Manual — cms.gov; accessed 2026-07-27.
4. ICD-10 Version:2016 — icd.who.int; accessed 2026-07-27.
5. P04.9 - Newborn affected by maternal noxious substance, unspecified | ICD-10-CM — unboundmedicine.com; accessed 2026-07-27.
6. Volume 1 – Tabular list - Tabular list of inclusions and four-character subcategories - XVI: Certain conditions originating in the perinatal period - P00-P04: Fetus and newborn affected by maternal factors and by complications of pregnancy, labour and delivery — classbrowser.nhs.uk; accessed 2026-07-27.