H10.419 Chronic giant papillary conjunctivitis, unspecified eye

ICD-10-CM H10.419: Chronic giant papillary conjunctivitis, unspecified eye

ICD-10-CM code H10.419 denotes chronic giant papillary conjunctivitis in an unspecified eye. Giant papillary conjunctivitis involves inflammation of the conjunctiva and is classified as a disease or syndrome. It arises from mechanical stimuli or foreign bodies, such as contact lenses, triggering an immune response. Chronic conjunctivitis is defined as lasting more than four weeks. 1 2 4

Plain-language overview

Giant papillary conjunctivitis is an ocular allergy arising from mechanical irritation or injury, such as contact lens use or ocular prostheses, which triggers an immune response involving Type I and Type IV hypersensitivity reactions. 1

Conjunctivitis involves inflammation of the conjunctival tissue, engorgement of blood vessels, pain, and ocular discharge, and is classified by duration as acute or chronic, with chronic conjunctivitis defined as lasting more than four weeks. 2

What this code represents

ICD-10-CM code H10.419 represents chronic giant papillary conjunctivitis in an unspecified eye and is classified under the semantic type of disease or syndrome. 4

The code H10.419 is one of several laterality designations for chronic giant papillary conjunctivitis, which includes distinct classifications for the right eye, left eye, bilateral eyes, and unspecified eye. 3

Documentation considerations

Clinical findings for giant papillary conjunctivitis include observations consistent with simple allergic conjunctivitis alongside giant papillae covering the tarsal conjunctiva, with infiltrating white blood cells such as plasma cells, mast cells, lymphocytes, basophils, and eosinophils. 1

Mechanically induced papillary conjunctivitis, or giant papillary conjunctivitis, is caused by various mechanical stimuli to the tarsal conjunctiva, and chronic papillary conjunctivitis may be present in patients with mucus fishing syndrome. 2

Coverage and utilization context

The supplied sources establish the clinical definition and semantic classification of H10.419 but do not provide payer-specific coverage policies, reimbursement guidelines, or utilization management rules for this diagnosis code. 1 4

What the sources add

Source S4 defines the code H10.419 as a disease or syndrome, while Source S3 lists the specific laterality variants for chronic giant papillary conjunctivitis, and Source S1 provides the underlying pathophysiology involving mechanical irritation and immune responses. 1 3 4

Questions to verify

The supplied sources do not establish whether the clinical documentation for H10.419 specifies the affected eye, and the sources do not indicate whether laterality was assessed during the encounter. 3 4

Sources

1. Bookshelf — ncbi.nlm.nih.gov; accessed 2026-07-25.
2. Bookshelf — ncbi.nlm.nih.gov; accessed 2026-07-25.
3. Phecode 371.2 · Cancer PRSweb — csg.sph.umich.edu; accessed 2026-07-25.
4. EVS Explore — evsexplore.semantics.cancer.gov; accessed 2026-07-25.