F16.22 Hallucinogen dependence with intoxication

ICD-10-CM F16.22: Hallucinogen dependence with intoxication

ICD-10-CM code F16.22 represents the diagnosis of hallucinogen dependence with intoxication, a substance use disorder characterized by a compulsive pattern of hallucinogen use resulting in significant impairment or distress. This active concept falls under the parent category of hallucinogen dependence and is classified as a mental or behavioral dysfunction. 1 4

Plain-language overview

F16.22 identifies a behavioral health condition where a person experiences a compulsive pattern of hallucinogen use that results in significant impairment or distress. 4

What this code represents

The code F16.22 is an active terminology record representing a mental or behavioral dysfunction, specifically hallucinogen dependence with intoxication. 1

In the ICD-10-CM hierarchy, F16.22 is a child concept of F16.2, which is the broader category for hallucinogen dependence, and it has no narrower subordinate concepts. 1

Coding details

Although F16.22 has no narrower subordinate concepts, 2026 ICD-10-CM includes related codes F16.220 for uncomplicated intoxication and F16.229 for unspecified intoxication. 1 5 6

Documentation considerations

The diagnostic approach for this condition involves a comprehensive clinical evaluation that adheres to the DSM-5 criteria for substance use disorders. 4

Clinical documentation for this diagnosis captures a clinical presentation that manifests with a range of cognitive, perceptual, and emotional symptoms. 4

What the sources add

While the terminology record defines the code's structural place in the classification system, clinical excerpts provide operational context regarding its multifactorial etiology involving genetic, environmental, and psychological components. 1 4

The terminology record establishes the official preferred name and active status, whereas clinical sources describe the condition's treatment as requiring a multidisciplinary approach tailored to individual needs. 1 4

Coverage and utilization context

The supplied clinical and coding references provide diagnostic criteria and code descriptions but do not establish specific payer coverage criteria or reimbursement rates for services billed under F16.22. 4 5

Sources

1. ICD-10-CM F16.22 terminology record — National Cancer Institute Enterprise Vocabulary Services; accessed 2026-07-27.
2. Bookshelf — ncbi.nlm.nih.gov; accessed 2026-07-27.
3. EVS Explore — evsexplore.semantics.cancer.gov; accessed 2026-07-27.
4. Hallucinogen dependence with intoxication — sprypt.com; accessed 2026-07-27.
5. F16.229 ICD-10-CM Code — Hallucinogen dependence with intoxication,… — simplepractice.com; accessed 2026-07-27.
6. F16.220 ICD-10-CM Code — Hallucinogen dependence with intoxication,… — simplepractice.com; accessed 2026-07-27.