C83.38 Diffuse large B-cell lymphoma, lymph nodes of multiple sites

ICD10CM code

#### Name of the Condition
- Diffuse Large B-Cell Lymphoma, Lymph Nodes of Multiple Sites
- ICD-10 Code: C83.38

#### Summary
Diffuse large B-cell lymphoma (DLBCL) is an aggressive type of non-Hodgkin lymphoma. It occurs when B-cells, a type of white blood cell, grow uncontrollably in multiple lymph node areas.

#### Causes
The exact cause of DLBCL is unknown. However, genetic mutations and disruptions in cell cycle regulations, infections like HIV or Epstein-Barr virus, and previous history of lymphoma are considered potential contributors.

#### Risk Factors
- Age, typically older adults
- Male gender
- Compromised immune system
- Previous cancer treatments
- Family history of lymphoma

#### Symptoms
- Swollen lymph nodes, often painless
- Fever
- Night sweats
- Unexplained weight loss
- Fatigue

#### Diagnosis
- Physical examination
- Imaging tests like CT or PET scans
- Biopsy of the lymph nodes
- Blood tests to evaluate cell counts and organ function

#### Treatment Options
- Chemotherapy: Often includes a regimen called R-CHOP
- Immunotherapy: Uses monoclonal antibodies like rituximab
- Radiation therapy: Focuses on affected lymph nodes
- Stem cell transplant: In some advanced cases

#### Prognosis and Follow-Up
While DLBCL is aggressive, many patients respond well to treatment, especially if detected early. Regular follow-ups and monitoring through imaging and blood tests are crucial to check for recurrence.

#### Complications
- Infections due to weakened immune system
- Treatment-related side effects like bone marrow suppression
- Potential spread to other organs without intervention

#### Lifestyle & Prevention
- No clear prevention methods due to unknown cause, but maintaining a healthy immune system is beneficial.
- Avoiding known risk factors, such as infections that can compromise immunity.

#### When to Seek Professional Help
Seek immediate medical attention if you experience persistent swelling of lymph nodes, unexplained fever, or significant fatigue, especially if you have risk factors.

#### Additional Resources
- American Cancer Society: [www.cancer.org](https://www.cancer.org)
- Lymphoma Research Foundation: [www.lymphoma.org](https://www.lymphoma.org)
- Leukemia & Lymphoma Society: [www.lls.org](https://www.lls.org)

#### Tips for Medical Coders
- Ensure specificity by including the site of involvement (multiple lymph nodes).
- Double-check combination codes and additional diagnoses for complications or related conditions.
- Avoid coding errors by confirming the presence of B-cell lymphoma through documentation.

Medical Policies and Guidelines for Diffuse large B-cell lymphoma, lymph nodes of multiple sites

Related policies from health plans

Similar Codes