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Injection, sulfamethoxazole and trimethoprim, 10 ml

HCPCS code

Name of the Procedure:

Injection, sulfamethoxazole and trimethoprim, 10 ml

  • Common names: Sulfa Injection, Bactrim Injection
  • Medical terms: Sulfamethoxazole and Trimethoprim Intravenous Injection, HCPCS Code S0039


In this procedure, a combination antibiotic called sulfamethoxazole and trimethoprim is administered via injection. This treatment is typically used to combat various bacterial infections by stopping the growth of bacteria.


  • Medical Conditions: This procedure treats bacterial infections such as urinary tract infections, bronchitis, and certain types of diarrhea.
  • Goals/Outcomes: The goal is to eliminate the bacterial infection and prevent its spread, thereby alleviating symptoms and preventing complications.


  • Symptoms/Conditions: Indicated for patients showing signs of bacterial infections like fever, pain, inflammation, and other localized or systemic symptoms.
  • Patient Criteria: Appropriate for patients who either cannot take oral antibiotics or require a higher concentration of the medication for severe infections.


  • Pre-procedure Instructions: Patients may be advised to avoid certain foods or medications before the injection; specific instructions will depend on individual cases.
  • Diagnostic Tests: Blood tests or urine cultures might be necessary to identify the type of bacteria and ensure the appropriateness of the antibiotic.

Procedure Description

  • Steps:
    1. The healthcare professional will clean the injection site (typically a vein in the arm).
    2. A sterile needle connected to a syringe filled with 10 ml of the antibiotic solution is prepared.
    3. The solution is injected slowly into the vein.
    4. Post-injection, the site is cleaned again, and a bandage may be applied.
  • Tools/Equipment: Sterile needle, syringe, antiseptic swabs, bandages.
  • Anesthesia: Not typically required; however, a topical numbing agent might be used if necessary.


The actual administration of the injection usually takes about 5-10 minutes.


This procedure is commonly performed in outpatient settings such as an outpatient clinic, hospital outpatient department, or even a surgical center.


  • Healthcare Professionals: Nurses or doctors typically administer the injection. In some cases, a nurse practitioner may be involved in the preparation.

Risks and Complications

  • Common Risks: Pain or redness at the injection site, mild allergic reactions.
  • Rare Risks: Severe allergic reactions, anaphylaxis, infection at the injection site, or kidney issues.
  • Management: Any adverse effects will be managed by medical professionals on-site, and severe reactions may require hospital admission.


  • Expected Benefits: Rapid alleviation of infection-related symptoms and prevention of bacterial spread.
  • Realization Time: Patients often notice improvement within a few days of treatment.


  • Post-procedure Care: Patients should monitor the injection site for signs of infection or adverse reactions.
  • Recovery Time: Generally immediate in terms of physical activity, but symptom relief depends on the severity of the infection. Follow-up may be necessary to ensure the infection has fully resolved.


  • Other Options: Oral antibiotics, alternative antibiotic injections, or other antimicrobial therapies.
  • Pros and Cons: Oral antibiotics are less invasive but may not be suitable for severe infections. Alternative antibiotics may be used based on bacterial resistance profiles.

Patient Experience

  • During the Procedure: Patients may feel a pinch or slight pain during the injection.
  • After the Procedure: Some soreness at the injection site is common. Pain management measures may include over-the-counter pain relievers and ice packs.

Pain and discomfort are generally minimal and manageable, making this procedure a practical option for those requiring intravenous antibiotics.

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