Name of the Procedure:

Platelets, pheresed; leukocytes reduced, CMV-negative, irradiated, each unit (P9053)

• Common Name: Irradiated Platelet Transfusion
• Medical Terms: Pheresis Platelets, Leukocyte-Reduced Platelets, CMV-Negative, Irradiated Platelets

Summary

This procedure involves transfusing platelets that have been collected through apheresis, reduced in white cells (leukocytes), tested to be cytomegalovirus (CMV) negative, and treated with irradiation. It is used to support patients with low platelet counts or platelet dysfunction.

Purpose

This specialized platelet transfusion is used to:

• Increase platelet counts in patients with bleeding disorders or low platelet counts.
• Prevent CMV transmission in immunocompromised patients.
• Reduce the risk of transfusion-associated graft-versus-host disease (TA-GvHD).

Indications

• Patients with thrombocytopenia (low platelet counts) due to cancer, chemotherapy, or bone marrow disorders.
• Immunocompromised patients who need a CMV-negative blood supply (e.g., organ transplant recipients, newborns).
• Patients requiring reduced leukocyte counts to minimize adverse reactions.

Preparation

• No specific fasting required.
• Inform your healthcare provider of any medications or allergies.
• Blood samples may be taken for cross-matching and compatibility testing.

Procedure Description

1. A blood sample is drawn from the donor and platelets are separated through apheresis.
2. The platelets are treated to remove leukocytes.
3. The unit is tested to ensure it is CMV-negative.
4. The platelets are irradiated to deactivate any residual white blood cells.
5. The transfusion is administered through an IV, typically in a hospital setting.
   • No anesthesia is required.

Duration

The transfusion itself usually takes 1-2 hours.

Setting

Typically performed in a hospital or specialized outpatient clinic.

Personnel

• Hematologist or Transfusion Medicine Specialist
• Registered Nurses
• Lab Technicians for preparation and testing

Risks and Complications

• Common: Mild allergic reactions, fever, chills
• Rare: Transfusion reactions, infection, TA-GvHD, lung complications

Benefits

• Rapid increase in platelet count
• Reduced risk of CMV and TA-GvHD
• Improved ability to manage bleeding disorders

Recovery

• Vital signs monitored post-transfusion.
• Rest may be recommended for a few hours.
• Follow-up blood tests to check platelet levels.
• Watch for any signs of adverse reactions.

Alternatives

• Whole blood transfusions: Higher risk of reactions.
• Autologous platelet transfusion: Only possible if planned in advance.
• Platelet growth factors: Slower onset.

Patient Experience

• Minor discomfort from the IV.
• Monitoring during and after the procedure.
• Generally, well-tolerated with minimal pain.
• Immediate care available if any reaction occurs.

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