Name of the Procedure:

Injection, Factor VIII FC Fusion Protein (Recombinant)
Common Name(s): Hemophilia A Injection
Technical/Medical Term: J7205

Summary

This procedure involves the injection of a recombinant Factor VIII FC fusion protein into the bloodstream. It is used to treat and prevent bleeding episodes in patients with hemophilia A, a genetic bleeding disorder due to deficiency or malfunction of clotting factor VIII.

Purpose

The procedure aims to:

• Replace the missing or deficient factor VIII in patients with hemophilia A.
• Prevent bleeding episodes.
• Manage acute bleeding events to prevent excessive blood loss and complications.

Indications

• Diagnosed hemophilia A (congenital or acquired).
• Ongoing or anticipated bleeding episodes.
• Preparatory or preventive measure before surgical or dental procedures.

Preparation

• Patients may be advised to hydrate well before the procedure.
• No specific fasting is generally required.
• Regular medications should be reviewed and possibly adjusted by the healthcare provider.
• Baseline blood tests to measure factor VIII levels and overall coagulation status might be performed.

Procedure Description

1. The patient is seated or lying comfortably.
2. The healthcare provider cleans the injection site, typically the forearm or the upper arm.
3. The recombinant Factor VIII FC fusion protein is drawn into a syringe.
4. The solution is injected slowly into the vein.
5. The injection site is observed for any immediate adverse reactions.

Duration

The injection itself takes about 5 to 10 minutes, including preparation and administration.

Setting

This procedure is typically performed in:

• Outpatient clinic
• Hospital
• Hemophilia treatment center

Personnel

• Licensed nurse
• Hematologist or treating physician
• Occasionally, a pharmacist may prepare the recombinant Factor VIII solution.

Risks and Complications

• Common: Injection site reactions (pain, redness, swelling)
• Rare: Allergic reactions, formation of inhibitors (antibodies against the factor VIII FC protein), thrombosis (if overdosed).

Benefits

• Prevention of bleeding episodes.
• Reduced need for emergency care due to bleeding.
• Improved quality of life and ability to participate in daily activities.
• Benefits can be realized within minutes to hours post-administration.

Recovery

• Patients can usually resume normal activities immediately after the procedure.
• Keep the injection site clean and observe for any signs of infection.
• Follow-up appointments might be scheduled to monitor factor VIII levels and overall health.

Alternatives

Other treatment options include:

• Plasma-derived factor VIII injections.
• Other recombinant factor VIII products.
• Desmopressin (for mild cases).
• The pros of the described procedure include longer half-life and less frequent dosing compared to some alternatives.

Patient Experience

• The patient might feel a brief pinch during needle insertion and mild discomfort at the injection site.
• During and after the procedure, it is generally well-tolerated.
• Pain management typically isn't necessary, but over-the-counter pain relief can be taken if needed.