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Amoxicillin, with or without clavulanate, not prescribed as first line antibiotic at the time of diagnosis for documented reason

HCPCS code

Name of the Procedure:

Amoxicillin, with or without clavulanate, not prescribed as first-line antibiotic at the time of diagnosis for a documented reason (HCPCS Code G9313).


This procedure involves the use of Amoxicillin, with or without clavulanate, as an antibiotic treatment, but it is not prescribed as the initial treatment when a diagnosis is made. There is a documented reason for choosing an alternative first-line antibiotic.


Amoxicillin is used to treat bacterial infections. The goal is to effectively manage infection while considering the patient's medical history, allergies, or bacterial resistance patterns to ensure the most effective treatment.


  • Bacterial infections requiring antibiotic treatment.
  • Conditions where first-line antibiotics (e.g., penicillin, cephalosporins) are unsuitable due to patient-specific factors.
  • Documented antibiotic resistance.
  • Patient allergies to standard first-line antibiotics.


  • Pre-procedure assessment involves reviewing the patient's medical history and any previous antibiotic responses or allergies.
  • Diagnostic tests like bacterial cultures and sensitivity testing may be conducted to pinpoint the most effective antibiotic.

Procedure Description

  1. Diagnosis: Confirm the bacterial infection through clinical evaluation.
  2. Documentation: Document the rationale for not using first-line antibiotics.
  3. Prescription: Prescribe Amoxicillin, with or without clavulanate, based on the infection's nature and patient factors.
  4. Administration: The antibiotic can be given orally or intravenously, depending on the site's and severity of the infection.


  • Prescription pad or electronic medical record system for prescription.
  • Oral or intravenous administration tools, if applicable.

No anesthesia or sedation is required.


The prescription process and initial diagnostic assessments can typically be completed within a single healthcare visit.


This is usually done in an outpatient setting, such as a doctor's office or clinic, though hospital settings are also possible for more severe cases.


  • Physicians, particularly primary care doctors or infectious disease specialists.
  • Nurses or medical assistants for administering the medication if intravenous treatment is necessary.

Risks and Complications

Common risks:

  • Allergic reactions (ranging from rash to anaphylaxis)
  • Gastrointestinal upset (nausea, vomiting, diarrhea)

Rare complications:

  • Antibiotic resistance development
  • Secondary infections

Management involves discontinuing the antibiotic if severe reactions occur and managing symptoms.


  • Effective treatment of the bacterial infection.
  • Avoidance of first-line antibiotics that may not be suitable.
  • Rapid symptom relief within a few days of starting treatment.


  • Adherence to the full course of prescribed antibiotics.
  • Follow-up visits to ensure the infection has fully resolved.
  • Avoid alcohol and certain food interactions based on medical advice.


  • Other antibiotics such as cephalosporins, macrolides, or quinolones depending on the infection and patient tolerance.

Pros: Potentially better suited for specific infections or patient conditions. Cons: Different side effect profiles, possible interaction with other medications.

Patient Experience

Patients may experience mild gastrointestinal discomfort but will otherwise generally continue their normal activities. Pain management typically involves over-the-counter medications if needed. Consistent follow-up ensures full recovery and management of any side effects.

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