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Supplies for maintenance of non-insulin drug infusion catheter, per week (list drugs separately)

HCPCS code

Name of the Procedure:

Maintenance of Non-Insulin Drug Infusion Catheter, per week

  • Technical Term: HCPCS Code A4221


This procedure involves regular maintenance of a catheter used for the infusion of non-insulin medications. The maintenance is required to ensure the catheter remains unobstructed and safe for ongoing drug administration.


  • Medical Conditions: This procedure is crucial for patients requiring continuous or intermittent infusion of non-insulin medications for managing various chronic conditions, such as pain management, chemotherapy, or other therapies.
  • Goals and Expected Outcomes: The objective is to prevent complications such as infections or blockages in the catheter, ensuring that the medication is effectively delivered.


  • Symptoms/Conditions: Patients with chronic conditions requiring long-term infusion therapy.
  • Patient Criteria: Suitable for patients with a pre-existing non-insulin drug infusion catheter.


  • Instructions: Patients may be advised to avoid consuming certain foods or medications that could interfere with the procedure or the medication being infused. Follow specific instructions provided by the healthcare team.
  • Diagnostic Tests/Assessments: Routine blood tests or imaging may be required to ensure there are no underlying issues before maintenance.

Procedure Description

  1. Sanitization: Healthcare provider will sanitize the area around the catheter.
  2. Inspection: Inspect the catheter for any signs of infection or blockage.
  3. Flushing: Use a saline solution or heparin to flush the catheter, ensuring it remains unobstructed.
  4. Dressing Change: Change the dressing around the catheter site to maintain hygiene.
  5. Documentation: Document the procedure, noting any issues or abnormalities.
    • Tools: Saline or heparin flush, sterile gloves, antiseptic solution, new dressing materials.
    • Anesthesia/Sedation: Typically not required.


The procedure usually takes about 15-30 minutes.


Performed in an outpatient clinic, hospital, or home healthcare setting.


  • Primary care nurse or specialized nurse.
  • Occasionally a physician may be consulted if there are complications.

Risks and Complications

  • Common Risks: Minor discomfort, slight risk of infection at the catheter site.
  • Rare Risks: Catheter displacement, severe infection, blockage of catheter.


  • Ensures continuous and uninterrupted delivery of essential medications.
  • Helps in maintaining the effectiveness of the ongoing therapy.
  • Reduced risk of complications associated with untreated catheter issues.
  • Benefits typically realized immediately after the procedure.


  • Post-Procedure Care: Keep the catheter site clean and dry, follow any additional care instructions given.
  • Recovery Time: No significant recovery time; patients can resume normal activities immediately.
  • Follow-Up: Scheduled weekly maintenance or as directed by the healthcare provider.


  • Other Options: Oral or injectable medication as an alternative to infusion therapy.
  • Pros and Cons:
    • Oral Medication: Easier to administer but may not be as effective for certain treatments.
    • Injectables: Similarly effective but may require more frequent administration.

Patient Experience

  • During Procedure: Minor discomfort while cleaning and flushing the catheter.
  • After Procedure: Generally no pain; slight soreness at the catheter site might be experienced.
  • Pain Management: Over-the-counter pain relievers may be recommended for minor discomfort.

Medical Policies and Guidelines for Supplies for maintenance of non-insulin drug infusion catheter, per week (list drugs separately)

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