3315F Estrogen receptor (ER) or progesterone receptor (PR) positive breast cancer (ONC)

Name of the Procedure:

Estrogen Receptor (ER) or Progesterone Receptor (PR) Positive Breast Cancer Treatment

Summary

Treatment for ER or PR positive breast cancer involves targeting hormone receptors on cancer cells that allow the cancer to grow in the presence of the hormones estrogen or progesterone. These receptors are detected through testing and treatment commonly involves hormone therapy to block these hormones.

Purpose

This treatment addresses breast cancer characterized by the presence of estrogen or progesterone receptors. The goal is to inhibit cancer growth by blocking or lowering hormone levels. Expected outcomes include reducing the size of tumors, slowing cancer progression, and decreasing the risk of cancer recurrence.

Indications

• Diagnosis of breast cancer with positive estrogen and/or progesterone receptors.
• Suitable for postmenopausal and premenopausal women.
• Presence of hormone receptor-positive breast cancer confirmed through biopsy.

Preparation

• No special fasting required.
• Patients may need to undergo diagnostic tests such as a biopsy to confirm the presence of hormone receptors.
• Inform the healthcare provider of any medications being taken.

Procedure Description

• Hormone therapy is administered, which may include medications such as tamoxifen or aromatase inhibitors.
• Oral medications are commonly taken daily.
• Injectable medications targeting hormone receptors may be given periodically according to the treatment plan.
• Regular monitoring through blood tests and imaging may be required to assess effectiveness.

Duration

• Hormone therapy treatment may continue for several years, typically ranging from 5-10 years depending on the individual case.

Setting

• Treatment can be managed in an outpatient clinic, hospital, or at home depending on the specific medication regimen.

Personnel

• Oncologist
• Nurses
• Pharmacists
• Radiologists for imaging follow-ups

Risks and Complications

• Common: Hot flashes, night sweats, fatigue, and bone loss.
• Rare: Increased risk of blood clots, endometrial cancer (in the case of tamoxifen), and heart problems.
• Management includes regular monitoring and addressing side effects as they arise.

Benefits

• Reduction in tumor size and slower progression of cancer.
• Decreased risk of cancer recurrence.
• Improved long-term survival rates.
• Benefits are often realized after several months of consistent treatment.

Recovery

• Minimal recovery time needed as hormone therapy is typically non-invasive.
• Patients can usually continue with daily activities.
• Regular follow-up appointments required to monitor treatment progress and manage any side effects.

Alternatives

• Surgery (lumpectomy or mastectomy) to remove the tumor.
• Chemotherapy and radiation therapy.
• Alternative therapies may have different risks and benefits, and in some cases, a combination of therapies may be recommended.

Patient Experience

• Patients may experience mild to moderate side effects like hot flashes and fatigue.
• Regular check-ups and monitoring are part of the routine.
• Pain management and comfort measures include lifestyle adjustments and medications to manage side effects.