Histocompatibility Testing Form

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Histocompatibility Testing for Kidney Transplant

Indications

(602085) Is the histocompatibility testing being performed in preparation for a kidney transplant? 

Histocompatibility Testing for Bone Marrow Transplantation

Indications

(602086) Is the histocompatibility testing being performed in preparation for bone marrow transplantation? 

Histocompatibility Testing for Blood Platelet Transfusions

Indications

(602087) Is the histocompatibility testing being performed in preparation for blood platelet transfusions and particularly where multiple infusions are involved? 

Histocompatibility Testing for Ankylosing Spondylitis

Notes: Coverage for ankylosing spondylitis requires documentation supporting medical necessity.

Indications

(602088) Is the histocompatibility testing being requested for suspected ankylosing spondylitis? 

Effective Date

07/31/2023

Last Reviewed

NA

Original Document

  Reference



Background for this Policy

Histocompatibility testing involves the matching or typing of the human leucocyte antigen (HLA).

This testing is safe and effective when it is performed on patients:

A. In preparation for a kidney transplant;

B. In preparation for bone marrow transplantation;

C. In preparation for blood platelet transfusions (particularly where multiple infusions are involved); or

D. Who are suspected of having ankylosing spondylitis.

This testing is covered under Medicare when used for any of the indications listed in A, B, and C and if it is reasonable and necessary for the patient.

It is covered for ankylosing spondylitis in cases where other methods of diagnosis would not be appropriate or have yielded inconclusive results. Request documentation supporting the medical necessity of the test from the physician in all cases where ankylosing spondylitis is indicated as the reason for the test.

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