T80.910A Acute hemolytic transfusion reaction, unspecified incompatibility, initial encounter

ICD-10-CM T80.910A: Acute hemolytic transfusion reaction, unspecified incompatibility, initial encounter

ICD-10-CM code T80.910A identifies an initial encounter for an acute hemolytic transfusion reaction involving unspecified incompatibility. This diagnosis represents a pathologic function where a patient's immune system destroys transfused red blood cells, representing a serious transfusion complication. The code holds an active record status. 1 3 5

Plain-language overview

A hemolytic transfusion reaction is a serious complication occurring after a blood transfusion when the recipient's immune system destroys the donated red blood cells, with symptoms most often appearing during or immediately after the procedure. 3

What this code represents

The code T80.910A represents a pathologic function specifically defined as an acute hemolytic transfusion reaction with unspecified incompatibility, and it is designated for the initial encounter. 1 5

Coding details

Within the ICD-10-CM terminology, T80.910A is an active code that possesses a parent concept, T80.910, and exists alongside distinct subsequent encounter and delayed reaction codes. 1 4

The code T80.910A is distinguished from other initial encounter codes that specify ABO, Rh, or non-ABO incompatibilities, as well as from codes for delayed hemolytic transfusion reactions. 4

Documentation considerations

Clinical documentation for this condition involves testing blood samples from both the donor and the recipient to determine whether symptoms are caused by a transfusion reaction. 3

Clinical context

Patients with sickle cell disease face a higher incidence of red blood cell alloimmunization, which increases the risk of hemolytic transfusion reactions that may be under-recognized because symptoms mimic acute vaso-occlusive crises. 2

What the sources add

While the terminology record establishes the code's classification as a pathologic function, the clinical source explains the underlying immune destruction of red blood cells that defines this serious complication. 1 3

The terminology source provides the official code hierarchy and active status, whereas the phecode listing demonstrates how this specific initial encounter code relates to other incompatibility and timing variants. 1 4

Sources

1. ICD-10-CM T80.910A terminology record — National Cancer Institute Enterprise Vocabulary Services; accessed 2026-07-27.
2. Hemolytic transfusion reactions in sickle cell disease: underappreciated and potentially fatal — pmc.ncbi.nlm.nih.gov; accessed 2026-07-27.
3. Hemolytic transfusion reaction: MedlinePlus Medical Encyclopedia — medlineplus.gov; accessed 2026-07-27.
4. Phecode 1011 · ExPRSweb — csg.sph.umich.edu; accessed 2026-07-27.
5. EVS Explore — evsexplore.semantics.cancer.gov; accessed 2026-07-27.