T80.59 Anaphylactic reaction due to other serum

ICD-10-CM T80.59: Anaphylactic reaction due to other serum

ICD-10-CM code T80.59 represents an anaphylactic reaction due to other serum, functioning as a pathologic function concept within the broader T80.5 parent category for serum-induced anaphylaxis. The terminology record is active and currently lists no narrower child concepts. This reference summarizes terminology details without providing personalized medical advice. 1

Plain-language overview

Code T80.59 identifies a pathologic function described as an anaphylactic reaction caused by other serum, providing a standardized diagnostic label for this specific health status. 1

What this code represents

The concept T80.59 is an active terminology entry with the preferred name anaphylactic reaction due to other serum, and the official record specifies that it has no narrower child concepts. 1

Within the ICD-10-CM hierarchy, T80.59 is classified directly beneath the parent concept T80.5, which covers an anaphylactic reaction due to serum generally. 1

Coding details

The parent category T80.5 includes specific exclusion notes for other serum reactions coded as T80.6- and adverse effects of correctly administered medicinal substances coded as T88.6. 4

A billing and coding article lists the phrase anaphylactic reaction due to other serum alongside T80.61XA, which denotes another serum reaction with an initial encounter character. 3

Documentation considerations

Clinical evaluation of suspected anaphylaxis involves assessing airway, breathing, and circulation stability, alongside obtaining an acute-phase serum tryptase level as early as possible during the event. 2

What the sources add

While the terminology record defines the diagnostic label for T80.59, the clinical reference provides operational context for evaluating allergic reactions by recommending acute-phase serum tryptase testing. 1 2

The parent code record adds inclusion terms such as anaphylactic shock due to serum and anaphylactoid reaction due to serum, while also excluding anaphylactic shock not otherwise specified. 4

Sources

1. ICD-10-CM T80.59 terminology record — National Cancer Institute Enterprise Vocabulary Services; accessed 2026-07-27.
2. Bookshelf — ncbi.nlm.nih.gov; accessed 2026-07-27.
3. Article - Billing and Coding: Allergy Testing (A57473) — cms.gov; accessed 2026-07-27.
4. ICD-10-CM T80.5: Anaphylactic reaction due to serum | Vero — veroscribe.com; accessed 2026-07-27.