T41.3X5 Adverse effect of local anesthetics

ICD-10-CM T41.3X5: Adverse effect of local anesthetics

ICD-10-CM code T41.3X5 represents the adverse effect of local anesthetics, functioning as an active diagnosis concept within the system. It falls under the parent category of poisoning, adverse effects, and underdosing of local anesthetics. Clinical literature notes that while local anesthetics are widely used, they carry documented risk factors for adverse events. 1 2

Plain-language overview

Code T41.3X5 identifies a diagnosis representing an adverse effect resulting from the administration of local anesthetics, which are medications utilized across various clinical settings. 1 2

What this code represents

The terminology record assigns T41.3X5 the preferred name of adverse effect of local anesthetics, classifies its semantic type as injury or poisoning, and maintains an active status. 1

This diagnosis code is a narrower concept without further subdivisions, distinguishing it from accidental poisoning by local anesthetics, which is classified under a separate specific code. 1 3

Coding details

In the ICD-10-CM hierarchy, T41.3X5 is categorized under the parent concept T41.3X, which encompasses poisoning, adverse effects, and underdosing of local anesthetics. 1

Documentation considerations

Clinical documentation for this code involves recording an adverse effect, and clinical literature indicates that risk factors include individual comorbidities, specific compounds, and administration techniques. 1 2

Practitioners documenting adverse events may consider that risk factors encompass site of administration, bolus injection without aspiration test, and large total local anesthetic dose. 2

What the sources add

While the terminology record provides the official code definition and hierarchy, the clinical update literature contributes operational context regarding the risk factors and clinical settings of local anesthetics. 1 2

The clinical update literature discusses adverse effects associated with local anesthetic and steroid use in regional anesthesia and acute or chronic pain treatment, whereas the terminology record lacks clinical usage context. 1 2

Coverage and utilization context

The terminology record establishes the code as an active diagnosis concept, but neither the terminology record nor the clinical literature establishes payer-specific coverage or reimbursement guidelines for this code. 1 2

Sources

1. ICD-10-CM T41.3X5 terminology record — National Cancer Institute Enterprise Vocabulary Services; accessed 2026-07-27.
2. LOCAL ANESTHETICS AND STEROIDS: CONTRAINDICATIONS AND COMPLICATIONS – CLINICAL UPDATE — pmc.ncbi.nlm.nih.gov; accessed 2026-07-27.
3. EVS Explore — evsexplore.semantics.cancer.gov; accessed 2026-07-27.