P61.4 Other congenital anemias, not elsewhere classified

ICD-10-CM Code P61.4: Other congenital anemias, not elsewhere classified

ICD-10-CM code P61.4 is labeled "Other congenital anemias, not elsewhere classified" in the CMS ICD-10-CM/PCS MS-DRG v33 Definitions Manual. Public source excerpts from PMC describe congenital hemolytic anemias and congenital dyserythropoietic anemias as hereditary disorders involving premature red blood cell destruction and ineffective erythropoiesis. The supplied sources do not explicitly map these clinical conditions to code P61.4. 1 2 3

Plain-language overview

The CMS ICD-10-CM/PCS MS-DRG v33 Definitions Manual includes an entry labeled "Other congenital anemias, not elsewhere classified" within its list of newborn and congenital condition codes. 3

What this code represents

The supplied CMS manual establishes the exact official display label "Other congenital anemias, not elsewhere classified" for this diagnosis code, but the manual excerpt does not provide a clinical definition for this specific entry. 3

Clinical context

Congenital hemolytic anemias are a group of intrinsic red blood cell disorders characterized by premature erythrocyte destruction and reduced red blood cell lifespan, while congenital dyserythropoietic anemias are hereditary disorders characterized by ineffective erythropoiesis and distinct bone marrow erythroblast morphologic abnormalities. 1 2

Congenital dyserythropoietic anemias are classified as disorders of erythropoiesis but involve the production of fragile red blood cells that undergo peripheral hemolysis, and they may be suspected in early life. 1 2

What the sources add

The CMS source provides the official diagnostic label for code P61.4, whereas the PMC sources describe the pathophysiology of specific congenital anemia groups, but neither set of excerpts explicitly links these clinical descriptions to the P61.4 code classification. 1 2 3

Documentation considerations

The PMC sources identify specific types of congenital dyserythropoietic anemias, including type I, type II, type III, and type IV, which represent distinct morphologic and molecular classifications of these hereditary disorders. 1 2

Questions to verify

To verify the application of code P61.4, a coder would need to confirm whether conditions such as congenital dyserythropoietic anemias or congenital hemolytic anemias are officially classified under this specific ICD-10-CM entry, as the supplied sources do not establish this mapping. 1 2 3

Sources

1. Severe Presentation of Congenital Hemolytic Anemias in the Neonatal Age: Diagnostic and Therapeutic Issues — pmc.ncbi.nlm.nih.gov; accessed 2026-07-25.
2. Congenital dyserythropoietic anemias: molecular insights and diagnostic approach — pmc.ncbi.nlm.nih.gov; accessed 2026-07-25.
3. ICD-10-CM/PCS MS-DRGv33 Definitions Manual — cms.gov; accessed 2026-07-25.