N46.029 Azoospermia due to other extratesticular causes

ICD-10-CM N46.029: Azoospermia due to other extratesticular causes

Azoospermia is a medical condition characterized by the absence of sperm in a man's ejaculate. The ICD-10-CM code N46.029 represents azoospermia due to other extratesticular causes. Public health and clinical sources establish that azoospermia can result from pre-testicular, testicular, or post-testicular factors, including hormonal imbalances and ductal obstructions. 2 3 4

Plain-language overview

Azoospermia is a medical condition characterized by the absence of sperm in a man's ejaculate. This condition can result from various underlying factors, including hormonal imbalances, obstructive or nonobstructive blockages in the reproductive tract, or certain genetic conditions. 2

What this code represents

The ICD-10-CM system includes a specific diagnostic designation for azoospermia due to other extratesticular causes. This designation is listed alongside related conditions such as azoospermia due to obstruction of efferent ducts and oligospermia due to other extratesticular causes. 3 4

Clinical context

Azoospermia can be subdivided into pre-testicular, testicular, or post-testicular causes. Post-testicular causes of azoospermia include any ductal obstruction at any site in the entire male reproductive tract. 2

Azoospermia can also be caused by ejaculatory dysfunction, such as retrograde ejaculation or anejaculation, which fall outside the realm of obstructive azoospermia or non-obstructive azoospermia. 1

Documentation considerations

The initial evaluation of an azoospermic patient includes a full medical history, physical examination, and measurement of serum testosterone and follicle-stimulating hormone levels. Measurement of follicle-stimulating hormone and testis volume is extremely useful in the evaluation of azoospermia. 1

In cases of a normal hormonal profile, a testicular biopsy can be used to evaluate spermatogenesis further. This biopsy would be the definitive way to diagnose azoospermia from causes like maturational arrest and Sertoli cell-only syndrome. 2

What the sources add

The Centers for Medicare and Medicaid Services ICD-10-CM manual and the ExPRSweb phecode database both list azoospermia due to other extratesticular causes as a recognized condition. These two sources provide identical text for this condition alongside related extratesticular and efferent duct diagnoses. 3 4

Coverage and utilization context

The supplied public sources establish clinical definitions and diagnostic classifications for azoospermia, but they do not address payer-specific coverage policies. Assigning a diagnosis code does not guarantee coverage or reimbursement for any associated medical services or treatments. 1 2 3 4

Sources

1. Case – Azoospermia with bilateral varicocele and normal folliclestimulating hormone — pmc.ncbi.nlm.nih.gov; accessed 2026-07-25.
2. Bookshelf — ncbi.nlm.nih.gov; accessed 2026-07-25.
3. Phecode 609.1 · ExPRSweb — csg.sph.umich.edu; accessed 2026-07-25.
4. ICD-10-CM/PCS MS-DRG v42.1 Definitions Manual — cms.gov; accessed 2026-07-25.